Registration Dossier
Registration Dossier
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EC number: 619-447-3 | CAS number: 99607-70-2
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-07-11 - 1991-12-17
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 0.59 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not reported
- Details on results:
- The solubility result is quoted to two significant figures.
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The study is considered to be adequate and reliable. - Executive summary:
Water solubility at 25 °C in pure water: 0.59 mg/L.
Reference
Centrifugation at different G values gave similar results demonstrating that clear solutions were obtained by centrifugation. Equilibration at 30.0 °C for different lengths of time also gave similar results indicating that true saturation was reached.
A comparison of the retention times of the substance in the reference solution with those of the substance in the sample solutions indicated that the identity of the test substance had not altered during the test. Hydrolysis products of the substance are, however, visible in the chromatograms of the sample solutions.
The substance is an extremely weak base with a pKa of 3.55. Therefore, the effect (if any) of pH in the pH range 5 to 9 on the water solubility of the substance may reasonably be assumed to be at most comparable with experimental error. Hence, at this relatively low level of solubility the variation of the determined solubility within the nine sampies will be larger than any possible pH dependency on the result.
Description of key information
Water solubility in pure water (Rodler, 25 °C): 0.59 mg/L.
Water solubility in buffered solutions (Kettner, 25 °C, pH 5.0): 0.54 mg/L
Water solubility in buffered solutions (Kettner, 25 °C, pH 7.0): 0.60 mg/L
Water solubility in buffered solutions (Kettner, 25 °C, pH 9.0): 0.47 mg/L
Key value for chemical safety assessment
- Water solubility:
- 0.59 mg/L
- at the temperature of:
- 25 °C
Additional information
Two guideline studies are available. Both are considered to be reliable and adequate. The study with pure water is considered more relevant, and is carried forward for use in risk assessment, classification and labelling.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
