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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 283-042-4 | CAS number: 84539-54-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Assessment of toxicokinetic behaviour based on toxicity data and on physico-chemical properties.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Technical Guidance Document on Risk Assessment, Part I, 2003
- Deviations:
- no
- GLP compliance:
- no
Test material
- Test material form:
- other: micro-granulated
Constituent 1
- Radiolabelling:
- other: not applicable
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- limited absorption into the body is expected
- Details on distribution in tissues:
- if absorbed, the substance is expected to be distributed into intravasal compartment
- Details on excretion:
- will beexcreted predominantly unchanged via the bile and the urine
Any other information on results incl. tables
Please see attached full version of toxicokinetic assessment (in section 13).
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Fe(3Na)EDDHSA has low absorption potential via all exposure routes. If absorbed, it is expected to be distributed predominantly in intravasal compartment. The substance is not expected to be metabolised and will be excreted mainly unchanged via the faeces or via the urine. - Executive summary:
Fe(3Na)EDDHSA is expected to be poorly absorbed after oral exposure, based on its water solubility and its insolubility in n-octanol. Concerning the absorption after exposure via inhalation, as the chemical is considered to have a low vapour pressure, is highly hydrophilic, insoluble in n-octanol, and has a rather high molecular weight, it is clear, that the substance is poorly available for inhalation and will not be absorbed significantly. In addition this is supported by the particle size distribution of Fe(3Na)EDDHSA which shows that only a minor amount will be available as the respirable fraction. Fe(3Na)EDDHSA is also not expected to be absorbed following dermal exposure into the stratum corneum and into the epidermis, due to its molecular weight and its high water solubility. Concerning its distribution in the body Fe(3Na)EDDHSA is expected to be distributed mainly in the intravasal compartment, due to its high water solubility. The substance does not indicate a significant potential for accumulation. Fe(3Na)EDDHSA is expected not to be significantly metabolised but to be eliminated unchanged via urine and bile.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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