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EC number: 225-218-5 | CAS number: 4724-48-5
Endpoint summary
Administrative data
Description of key information
Additional information
Fish
In a 96-h acute toxicity study, rainbow trout (Oncorhynchus mykiss) were exposed to OPA (Octylphosphonic Acid) at 40 mg/L nominal concentrations (limit test) under semi-static conditions according to the OECD guideline N° 203 (1992).
40 mg/L was considered to be the highest concentration which was possible to be dissolved in the media without precipitation of the substance. That why this test could be considered as a limit test.
The 96-h LC50was >40 mg/L
The NOEC values, based on mortality/sublethal effects, was 40 mg/L.
No sublethal effects were observed. Based on the results of this study, OPA would be not classified to fish.
Daphnia
The 48–hr-acute toxicity of OPA to Daphnia magna was studied under static conditions. Daphnids were exposed to control and test chemical at nominal concentration of 1.0, 1.8, 3.2, 5.6, 10, 18 and 32 mg/L for 48 hr. Immobility were observed daily.
The 48– hour EC50was > 32 mg/L.
The test was not carried at a concentration above than 32 mg/L because it was not possible to solubilize the subtance at a level upper than 32 mg/L in the medium (observations made during the range-finding study)
It satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates.
Results Synopsis
Test Organism :Daphnia magna
NOEC: 3.2 mg.//L
EC50: >32 mg/L
Algae
In a 72 hour acute toxicity study, the cultures of Pseudokirchneriella subcapitata were exposed to OPA at nominal concentrations of 1.0, 3.2, 10, 32 and 100 mg/L under static conditions in accordance with the OECD 201, after a range finding study at nominal concentration of 0.1, 1.0, 10 and 100 mg/L
Analytical verification showed an acceptable correlation between the nominal and the measured concentration.
The results were based on nominal concentration
The following results were determined:
NOEC Growth Rate and yield = 10 mg/L
EC 50 Growth rate= 40 mg/L with confidence limits of 35 -44 mg/L
EC 50 Yield = 23 mg/L with confidence limits of 20 -26 mg/L
All validity criteria were met, the test can be considered to be valid
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