Itaconic acid

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Report date:

1984

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Itaconic acid

EC Number:

202-599-6

EC Name:

Itaconic acid

Cas Number:

97-65-4

Molecular formula:

C5H6O4

IUPAC Name:

2-methylidenebutanedioic acid

Test animals

Species:

rabbit

Strain:

other: Albino New Zealand

Test system

Type of coverage:

semiocclusive

Preparation of test site:

other: intact skin

Vehicle:

water

Controls:

not specified

Amount / concentration applied:

2g/ml

Duration of treatment / exposure:

4 hours

Observation period:

the cutaneous primary irritation was evaluated on day 1 (1 hour after the removal of the pad) and on days 2, 3 and 4.

Number of animals:

Six male albino New Zealand rabbits

Details on study design:

six male albinorabbits were each administered a single dermal dose ofofitaconic acidmoistened with 0.25 ml distilled water. The test substance was applied on the intact skin for 4 hours. At the end of the treatment the semi‑occlusive dressing and gauze pad were removed and the cutaneous primary irritation was evaluated on day 1 (1 hour after the removal of the pad) and on days 2, 3 and 4.

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Time point:

other: 24 hrs

Score:

0

Max. score:

0

Any other information on results incl. tables

There were no signs of toxicity during the observation period. No dermal response to treatment was observed in any animal throughout the observation period.