Registration Dossier
Registration Dossier
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EC number: 209-599-5 | CAS number: 587-26-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given (comparable to guidelines/standards)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Guideline of the Department of Transportation (D.O.T), Code of Federal Regulations, Title 49, Part 173
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dilanthanum tricarbonate
- EC Number:
- 209-599-5
- EC Name:
- Dilanthanum tricarbonate
- Cas Number:
- 587-26-8
- Molecular formula:
- La2(CO3)3
- IUPAC Name:
- dilanthanum tricarbonate
- Details on test material:
- - Name of test material (as cited in study report): Rare Earth Carbonate #1451
- Molecular formula (if other than submission substance): La2(CO3)3*H2O
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Skippack Breeding Farm
- Weight at study initiation: intact skin: 3.055 kg, abraded skin: 3.083 kg
- Housing: individually in stainless steel suspended cage
- Diet (ad libitum): Putina Rabbit Chow
- Water: ad libitum
- Acclimation period: 7 days
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- rabbits were clipped free of fur over the entire upper back area (rabbits showing signs of dermal irritation or lesions were replaced)
- five of the test sites were abraded by making a series of five parallel superficial scratches in the dermis, the remaining five were left intact
- The test substance was applied at 2000 mg/kg bw to the shaved skin and wrapped with an impervious band which was left in place for 24 h. Where necessary, the animals were restrained or equipped with an "Elizabethan Collar" to prevent bandage removal.
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 10 (no information about sex, 5 with intact skin, 5 with abraded skin )
- Control animals:
- no
- Details on study design:
- - Animals were observed for mortality for up to 48 h
- Treatment sites were evaluated for signs of erythema or edema according to the Draize Scoring System at 24 and 48 h after removal of the patch
- Body weight was recorded at dosing
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 1 924 mg/kg bw
- Remarks on result:
- other: recalculated value to Lanthanum carbonate
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value: Lanthanum carbonate monohydrate
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: No changes were noted in skin condition during the test period.
- Gross pathology:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
