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Diss Factsheets
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EC number: 203-457-6 | CAS number: 107-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- sub-chronic toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: - non-GLP - very limited information on experimental details
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - 6 adult rabbitstreated with 3-chloropropene by subcutaneous injection, 50 mg/kg, 3 times in the first week, followed by 100 mg/kg, 3 times a week for 38-80 days, three rabbits as untreated controls
- divided into 3 groups and killed on the 38th, 54th and 80th day
- EMG measurements
- Histology on samples of the brain, cervical and lumbar spinal cord, sciatic and tibial nerves. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 3-chloropropene
- EC Number:
- 203-457-6
- EC Name:
- 3-chloropropene
- Cas Number:
- 107-05-1
- Molecular formula:
- C3H5Cl
- IUPAC Name:
- 3-chloroprop-1-ene
- Details on test material:
- No information was given about the test material, but as in the publication some of the results of LU 1982 were repeated and as there is an intersection in the two lists of authors it was concluded by the reviewer that they probably used the same material and therefore the information from Lu 1982 is presented here:
- Name of test material (as cited in study report): allyl chloride - Physical state: colorless liquid
- Analytical purity: either twice distilled (>99 %) or of a commercial grade with a purity of about 90%,
probably in the study presented her the 99 % pure substance was used
the use of the 90 % substance in the acute experiments was explicitely reported
- Lot/batch No.: not reported
- Stability under test conditions: stable
- Storage condition of test material: not reported
Confidential details on test material
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Six adult rabbits were given 3-chloropropene by subcutaneous injection, 50 mg/kg, 3 times in the first week, followed by 100 mg/kg, 3 times a week for 38-80 days.
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- single injection per day, 38 - 80 days
- Frequency of treatment:
- 3 d/wk
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50 mg/kg, 3 times in the first week, followed by 100 mg/kg,
- No. of animals per sex per dose:
- 6 animals, 2 sacrificed after 38 d, 54 d and 80 d
3 rabbits were used as normal controls. - Control animals:
- yes, concurrent no treatment
- Details on study design:
- no data
Examinations
- Observations and examinations performed and frequency:
- - EMG measurements
- Histology:
Tissue samples from the brain, cervical and lumbar spinal cord, sciatic and tibial nerves were fixed in 10% formalin and embeded with paraffin. Sections were stained with H.E. and some with Nissl's, Weil's, Gros-Bielschosky's or Masson's stain. - Sacrifice and pathology:
- The animals were divided into 3 groups and killed on the 38th, 54th and 80th day.
- Other examinations:
- not reported
- Statistics:
- no data
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not examined
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- effects observed, treatment-related
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- EMG measurement:
EMG abnormalities were found in all dosed animals at the 5th-6th week which were correlated with the severity of functional disability.
Histology:
Morphological study by light microscopy showed that peripheral nerve fibre degeneration was most marked in the distal portions of the nerves examined, although milder fibre changes were readily seen in the proximal portions. In severely damaged nerve fibres, a number of axons and myelin sheaths undergoing Wallerian degeneration had been replaced by clusters of vacuoles and foamy cells, while the milder fibre changes were an axonal irregular moniliform swelling associated with focal demyelination.
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 100
- Sex:
- not specified
- Basis for effect level:
- other: neurotoxic effects: peripheral nerve fibre degeneration, mainly in the distal portions of the nerves
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
In the present study (He 1985) 3 groups of 2 rabbits were treated with 100 mg/Kg bw of 3 -chloropropene via subcutaneous injection at 3 d/wk for 38, 54 and 80 d (first 3 injections only with 50 mg/Kg bw).
EMG measurements showed abnormalities in all dosed animals at the 5th-6th week which were correlated with the severity of functional disability.
Morphological study by light microscopy showed that peripheral nerve fibre degeneration was most marked in the distal portions of the nerves examined, although milder fibre changes were readily seen in the proximal portions. In severely damaged nerve fibres, a number of axons and myelin sheaths undergoing Wallerian degeneration had been replaced by clusters of vacuoles and foamy cells, while the milder fibre changes were an axonal irregular moniliform swelling associated with focal demyelination.
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