Registration Dossier
Registration Dossier
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EC number: 202-394-1 | CAS number: 95-14-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD-Guideline Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzotriazole
- EC Number:
- 202-394-1
- EC Name:
- Benzotriazole
- Cas Number:
- 95-14-7
- Molecular formula:
- C6H5N3
- IUPAC Name:
- benzotriazole
- Test material form:
- other: granules
- Details on test material:
- - Name of test material (as cited in study report): Benzotriazol
- Synonyms: Preventol CI8; Preventol CI8-100
- Substance type: pale yellow granules
- Physical state: solid
- Lot/batch No.: 909
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: HC:NZW
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Interfauna UK Ltd
- Weight at study initiation: 3.0 - 3.7 kg
- Housing: standard single animal cages
- Diet: ssniff K 4 ad libitum
- Water: ad libitum
- Acclimation period: two weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +- 2 °C
- Humidity (%): 45 - 65%
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 500 mg of substance
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 1, 24, 48, 72 hours, 7 and 14 days
- Number of animals:
- 3
- Details on study design:
- according to guideline
TEST SITE
- Area of exposure: 6 cm2
- Type of wrap if used: elastic gluing dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with water
- Time after start of exposure: 4h
SCORING SYSTEM: Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- not irritating
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Benzotriazole is not classified as irritating to the skin of rabbits.
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