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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Brief report, however giving sufficient experimental detail. Similar to guideline test methods.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1984
Report date:
1983

Materials and methods

Principles of method if other than guideline:
No guideline available at the time. Conduct similar to subsequently developed guidelines.
GLP compliance:
no
Test type:
other: limit test
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Galliumarsenid - Probably a mechanically destroyed material not marketed.
IUPAC Name:
Galliumarsenid - Probably a mechanically destroyed material not marketed.
Details on test material:
- Name of test material (as cited in study report): Galliumarsenid
no details available

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
Normal food and drinking water ad libitum. Room temperature 20°-24°, relative humidity 40-65%. Animal age at start of test 8-10 weeks. Average body weight 185.5 +- 18g.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: suspended in traganth solution (1%)
Details on oral exposure:
Animals were fasted 16 h before oral dosing.
Doses:
From the report it appears that several doses were tested. However, only the limit dose of 10000 mg/kg bw is actually stated.
No. of animals per sex per dose:
Not stated
Control animals:
not specified
Details on study design:
Observation period 14 days.
Statistics:
not available

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD0
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.
Mortality:
no mortality observed
Clinical signs:
other: general behaviour appeared unaffected
Gross pathology:
no substance related changes in organs observed

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

A single oral dosage of 10000 mg GaAs/kg bw was administered to female Wistar rats. The test article was suspended in 1% traganth solution. The rats were kept at room temperature 20°-24°, a relative humidity of 40-65% and with free access to food and water. Animal age at start of test was 8-10 weeks and the average body weight 185.5 +- 18g. The observation period after administration was 14 days. No substance related changes were observed with the animals. Study design similar to guideline test method.

LD50 rat, female, oral > 10000mg GaAs/kg bw.