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EC number: 221-435-4 | CAS number: 3091-25-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Eye irritation, 001: A primary irritation index of 80 for the cornea, 10 for the iris, and 16.8 for the conjunctivae of the rabbit eye was recorded in the study. These values corresponds to the highest values according to the scoring system. The mean scores at 24, 48 and 72 hours are 4 and 2 for the cornea and iris respectively according to the scoring system, these value are greater than the values stated in the DSD (67/548/EEC) and CLP (1272/2008) regulations, and therefore the test substance will be classified accordingly. It should also be noted that the effects had not reversed by 7 days.
Skin irritation, 001: No erythema was observed in any animals at 24 or 72 hours. Edema formation was noted in all 6 animals, the mean 24 and 72 hour edema scores were 3.33 and 2.17 respectively. Although there are no 48 hour scores recorded it is considered that the 48 hour scores would not have been any lower than the 72 hour scores. With this in mind the mean edema score would be considered to greater than the the values stated in the DSD (67/548/EEC) and CLP (1272/2008) regulations, and therefore the test substance will be classified accordingly. It should also be noted that effects had not reversed by 7 days.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The eye irritation potential of octyltin trichloride was investigated in 6 New Zealand white rabbits. The cornea was scored on the basis of degree of opacity, and area involved. The iris was scored for the presence of folds, congestion, swelling, circumcorneal injection, reaction to light, hemorrhage and gross destruction. The conjunctivae were scored for redness, chemosis, and discharge. The maximum scores for the cornea, iris, and conjunctivae were 80, 10, and 20, respectively. Trichlorooctylstannane had a primary irritation index of 80 for the cornea, 10 for the iris, and 16.8 for the conjunctivae. Therefore, it was considered a severe irritant to the rabbit eye.
The dermal irritation potential of octyltin trichloride was investigated in 6 New Zealand white rabbits. Skin reactions were scored on a scale of 0 - 4 for erythema and eschar formation as well as edema. An average of all 6 animals for intact and abraded skin at 24 and 72 hours was calculated (primary dermal irritation index). The test sites did not show any erythema, but showed necroses and edema. Symptoms did not disappear or diminish during the 7 -day observation period. Octyltin trichloride had a primary dermal irritation index of 1.4 in rabbits which was characterised as a slight irritant to the skin of rabbits.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: highly irritating
Justification for classification or non-classification
On the basis of the eye scores, trichlorooctylstannane is considered an eye irriant, with risk of serious damage to eyes. Particularly obvious is the cornea, which achieved the maximum score of 80. Trichlorooctylstannane is therefore classified as Xi; R41 according to the DSD and a category 1 eye irritant according to the CLP with a danger signal word and hazard phrase H318.
On the basis of the edema response, trichlorooctylstannane is considered a skin irritant. The mean oedema score is 2.75, which classifies trichlorooctylstannane as a skin irritant according to the DSD (67/548/EEC) and 5/6 rabbits have mean odema scores >2.3
which classifies trichlorooctylstannane as a skin irritant according to the CLP (1272/2008) regulations.
Therefore, according to the DSD, trichlorooctylstannane should be classified Xi; R38 and as a category 2 irritant under the CLP with the H315 hazard phrase and warning signal word.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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