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EC number: 700-182-8 | CAS number: 134652-60-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 May to 25 June 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Recent study conducted by a GLP certified laboratory in accordance with a suitable study guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.3110 (Ready Biodegradability)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Tripropan-2-ylsilyl 2-methylprop-2-enoate
- EC Number:
- 700-182-8
- Cas Number:
- 134652-60-1
- Molecular formula:
- C13 H26 O2 Si
- IUPAC Name:
- Tripropan-2-ylsilyl 2-methylprop-2-enoate
- Details on test material:
- - Name of test material (as cited in study report): TIS-M
- Lot/batch No.: 9925
- Expiration date of the lot/batch: 2 December
- Storage condition of test material: At room temperature: 15-25ºC
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge:The activated sludge was supplied from the sewage plant for domestic sewage in Veszprém, Hungary.
- Preparation of inoculum for exposure: The activated sludge used for this study was washed by centrifugation (for 10 min.) and the supernatant liquid phase was decanted. The solid material was re-suspended in isotonic saline solution and again centrifuged (for 10 min.). This procedure was repeated twice. An aliquot of the final sludge suspension was weighed, dried and the ratio of wet sludge to its dry weight was determined. Based on this ratio, calculated aliquots of washed sludge suspension, corresponding to 4 g dry material per litre were mixed with test water and then aerated until use. Before use the sludge was filtered through cotton wool.
- Concentration of sludge: 4 g dry material per litre. - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 2.9 mg/L
- Based on:
- COD
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Test temperature: 21.8-23.2°C in an incubator.
- pH: 7.40
- pH adjusted: no
- Aeration of dilution water:
- Suspended solids concentration:
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: BOD bottles (300 ml) with special neck and glass stoppers.
- Number of culture flasks/concentration: 10
- Method used to create aerobic conditions: The test medium was aerated for 20 minutes and allowed to stand for about 20 hours at the test temperature.
- Measuring equipment: The COD (chemical oxygen demand) of the test item were determined in using Lovibond® COD Measuring System and the oxygen concentrations were measured with oxygen meter with a stirring O2 electrode.
- Test performed in open system: yes
CONTROL AND BLANK SYSTEM
- Inoculum blank: inoculum control contains the inoculum only.
- Toxicity control: contains test item, reference item and inoculum.
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
- Preliminary study:
- The 14-d preliminary test measured the chemical oxygen demand (COD) to be 2.10 ±0.03 mg test item, which lead to the decision that the required test item concentration would be 2.9 mg/L for the study.
- Test performance:
- Based on the results observed, the test performance was acceptable and within current acceptable limits.
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 8.2
- Sampling time:
- 28 d
- Details on results:
- - Under the test conditions the percentage biodegradation of TIS-M reached a mean of 8.2 % after 28 days based on the measured COD of the test item. The test item can therefore be considered to be not ready biodegradable. According to the test guidelines the pass level for ready biodegradability is removal of 60 % ThOD.
- The reference item Sodium benzoate was sufficiently degraded to a mean of 82.5% after 14 days, and to a mean of 86.7 % after 28 days of incubation, based on ThODNH4, thus confirming the suitability of the used activated sludge inoculum.
- In the toxicity control containing both, the test item and the reference item Sodium benzoate, a mean of 45.3 % biodegradation was noted within 14 days and 46.6% biodegradation after 28 days of incubation. According to the test guidelines the test item can be assumed to be not inhibitory at the applied concentration level of 2.9 mg/L on the activated sludge microorganisms because degradation was >25 % within 14 days.
BOD5 / COD results
BOD5 / COD
- Parameter:
- COD
- Value:
- 2.1 mg O2/g test mat.
- Results with reference substance:
- The reference item Sodium benzoate was sufficiently degraded to a mean of 82.5% after 14 days, and to a mean of 86.7 % after 28 days of incubation, based on ThODNH4, thus confirming the suitability of the used activated sludge inoculum. According to the test guidelines the pass level for ready biodegradability is removal of 60 % ThOD.
Any other information on results incl. tables
Table 2. Dissolved Oxygen Concentrations at Different Time Intervals during the Exposure Period of 28 Days:
Treatment |
Concentration [mg/L] |
Flask No. |
0 |
mg O2/L after 7 |
n days of exposure 14 21 |
28 |
|
|
2.9 |
1a |
8.1 |
7.1 |
6.9 |
6.6 |
6.3 |
Test item |
2.9 |
1b |
8.1 |
7.1 |
7.0 |
6.6 |
6.4 |
|
2.9 |
mean |
8.10 |
7.10 |
6.95 |
6.60 |
6.35 |
|
3.6 |
2a |
8.2 |
2.7 |
2.5 |
2.1 |
1.7 |
Reference item |
3.6 |
2b |
8.2 |
2.7 |
2.3 |
2.1 |
1.8 |
|
3.6 |
mean |
8.20 |
2.70 |
2.40 |
2.10 |
1.75 |
|
- |
3a |
8.4 |
7.6 |
7.5 |
7.3 |
7.1 |
Inoculum control |
- |
3b |
8.3 |
7.5 |
7.5 |
7.2 |
7.1 |
|
- |
mean |
8.35 |
7.55 |
7.50 |
7.25 |
7.10 |
|
- |
4a |
8.1 |
2.1 |
1.7 |
1.4 |
1.1 |
Toxicity control |
Test item: 2.9 Reference item: 3.6 |
4b |
8.1 |
2.1 |
1.7 |
1.4 |
1.2 |
|
|
mean |
8.10 |
2.10 |
1.70 |
1.40 |
1.15 |
Table 3: Oxygen Depletion at Different Time Intervals during the Exposure Period of 28 Days
|
Concentration |
Flask |
|
mg O2/L after n |
days of exposure |
|
Treatment |
[mg/L] |
No. |
7 |
14 |
21 |
28 |
Test item |
2.9 |
1a |
0.20 |
0.35 |
0.40 |
0.55 |
|
|
|
|
|
||
Test item |
2.9 |
1b |
0.20 |
0.25 |
0.40 |
0.45 |
Reference item |
3.6 |
2a |
4.70 |
4.85 |
5.00 |
5.25 |
|
|
|
|
|
||
Reference item |
3.6 |
2b |
4.70 |
5.05 |
5.00 |
5.15 |
Toxicity |
Test item: 2.9 |
4a |
5.20 |
5.55 |
5.60 |
5.75 |
control |
Reference item: 3.6 |
4b |
5.20 |
5.55 |
5.60 |
5.65 |
oxygen depletion : (mt0 - mtx) - (mbo - mbx), where:
- mt0 : oxygen concentration (mg/L) of test group on day 0 (1a, 2a, 4a and 1b, 2b, 4b from Table 2)
- mtx: oxygen concentration (mg/L) of test group on day x (1a, 2a, 4a and 1b, 2b, 4b from Table 2)
- mb0: oxygen concentration (mg/L) of inoculum blank on day 0 (mean of 3a and 3b from Table 2)
- mbx: oxygen concentration (mg/L) of inoculum blank on day x (mean of 3a and 3b from Table 2)
Table 4. BOD at Different Time Intervals during the Exposure Period of 28 Days:
|
Concentration |
Flask |
|
BOD after n days of exposure |
|
|
Treatment |
[mg/L] |
No. |
7 |
14 |
21 |
28 |
Test item |
2.9 |
1a |
0.07 |
0.12 |
0.14 |
0.19 |
|
|
|
|
|
||
Test item |
2.9 |
1b |
0.07 |
0.09 |
0.14 |
0.16 |
Reference item |
3.6 |
2a |
1.31 |
1.35 |
1.39 |
1.46 |
|
|
|
|
|
||
Reference item |
3.6 |
2b |
1.31 |
1.40 |
1.39 |
1.43 |
Toxicity |
Test item: 2.9 |
4a |
0.80 |
0.85 |
0.86 |
0.88 |
control |
Reference item: 3.6 |
4b |
0.80 |
0.85 |
0.86 |
0.87 |
BOD = (mg O2 of T.i. and/or R.i.-mg O2 of i.control) / (mg T.i. and/or in R.i. in flask) = mg O2/mg T.i and/or R.i.
where: T.i. = test item R.i. = reference item i.control = inoculum control.
Table 5. Percentage Biodegradation at Different Time Intervals during the Exposure Period of 28 Days
Treatment |
Concentration [mg/L] |
Flask No. |
Percent of biodegradation after n days of exposure 7 14 21 28 |
|||
Test item |
2.9 |
1a |
3.3 |
5.7 |
6.6 |
9.0 |
Test item |
2.9 |
1b |
3.3 |
4.1 |
6.6 |
7.4 |
Test item |
2.9 |
mean |
3.3 |
4.9 |
6.6 |
8.2 |
Reference item |
3.6 |
2a |
78.3 |
80.8 |
83.3 |
87.5 |
Reference item |
3.6 |
2b |
78.3 |
84.2 |
83.3 |
85.8 |
Reference item |
3.6 |
mean |
78.3 |
82.5 |
83.3 |
86.7 |
|
|
4a |
42.5 |
45.3 |
45.7 |
47.0 |
Toxicity |
Test item: 2.9 |
4b |
42.5 |
45.3 |
45.7 |
46.2 |
control |
Reference item: 3.6 |
|
||||
|
|
mean |
42.5 |
45.3 |
45.7 |
46.6 |
Biodegradation % = (BOD ( mg O2/mg T.i. or R.i) / COD (mg O2/mg T.i.) or THODNH4 (mg O2/mg R.i.)) x100
where: T.i. = test item R.i. = reference item i.control = inoculum control.
COD of test item = 2.10 ± 0.03 mg O2/mg test item
ThODNH4 of reference item = 1.67 mg O2/mg reference item
The biodegradation in the toxicity control was calculated according to the following formula:
(BOD (mg O2/mg T.i. and R.i.) / [COD(mgO2/mgT.i.) + ThODNH4 (mg O2/mg R.i)]* 1/2) x 100
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- -The registered substance was determined to be not ready biodegradable, as the percentage biodegradation reached a mean of 8.2 % after 28 days based on the measured COD of the test item.
-In the toxicity control containing both the registered substance and the reference item Sodium benzoate, a mean of 45.3 % biodegradation was noted within 14 days and 46.6% biodegradation after 28 days of incubation. According to the test guidelines the test item can be assumed to be not inhibitory at the applied concentration level of 2.9 mg/L on the activated sludge microorganisms because degradation was >25 % within 14 days. - Executive summary:
The biodegradibility of the registered substance was assessed according to the EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test) method. Procedure, inoculum and toxicity controls were also used. After 28 days the registered substance was determined not to be ready biodegradable, as the percentage biodegradation reached a mean of 8.2 % after 28 days based on the measured COD of the test item. It was also determined that the registered substance can be assumed not to be inhibitory at the applied concentration level of 2.9 mg/L on the activated sludge microorganisms because degradation was >25 % within 14 days, according to the results of the toxicity control and the guideline used.
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