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EC number: 210-036-0 | CAS number: 603-35-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: test procedure in accordance with generally accepted standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: The acute dermal toxicity to rabbits was evaluated according to a BASF-internal standard method by a single application of an 50% alcoholic suspension to the shaven dorsal skin of 3 male and 3 female animals, equivalent to a dose of 4000 mg/kg test material. During 24 hour exposure period, the exposed skin area of 355 cm2 was covered with parchment paper and overlying bandages and the animals were restrained. After application, the animals were observed for 14 days for mortality and syptoms of acute intoxication or local irritation. Animals were evaluated for gross pathological changes. The mean lethal dose was determined
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Triphenylphosphine
- EC Number:
- 210-036-0
- EC Name:
- Triphenylphosphine
- Cas Number:
- 603-35-0
- Molecular formula:
- C18H15P
- IUPAC Name:
- triphenylphosphine
- Test material form:
- solid: crystalline
Constituent 1
- Specific details on test material used for the study:
- - Purity: 99%
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final dilution of a dissolved solid, stock liquid or gel: 50% alcoholic suspension
FORM AS APPLIED IN THE TEST (if different from that of starting material): suspension
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: 2/6 bred by the medical-biological research laboratory of BASF, 4/6 purchased.
- Weight at study initiation: average 3,24 kg.
- Diet (e.g. ad libitum): yes.
- Water (e.g. ad libitum): yes.
IN-LIFE DATES: From: 14.10.1971 To: 28.10.1971.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- ethanol
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 355 cm2.
- Type of wrap if used: the application area was covered with parchment paper and overlying bandages.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): approx. 10 mL.
- Concentration (if solution): 50 %. - Duration of exposure:
- 24 hours
- Doses:
- 4000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days.
- Frequency of observations: at least after 1h, 24h, 48h, 7d and 14d.
- Necropsy of survivors performed: yes.
- Other examinations performed: clinical signs, signs of local irritation.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- > 4 000 mg/kg bw
- Remarks on result:
- other: no mortalities
- Mortality:
- No mortalities occured.
- Clinical signs:
- other: No signs of acute intoxication and local irritation were observed.
- Gross pathology:
- Necropsy revealed no macroscopic and/or organ pathological findings related to TS exposure.
Any other information on results incl. tables
Table 1: Mortality
Dose [mg/kg] |
Concentration in alcohol [%] |
Number of animals |
Dead animals within | ||||
1 hour | 24 hours | 48 hours | 7 days | 14 days | |||
4000 | 50 | 3 male 3 female |
0 / 3 0 / 3 |
0 / 3 0 / 3 |
0 / 3 0 / 3 |
0 / 3 0 / 3 |
0 / 3 0 / 3 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 > 4000 mg/kg
- Executive summary:
The acute dermal toxicity of the test substance to rabbits was assessed according to a BASF-internal standard method. Therefore, the test substance was applied as an 50% alcoholic suspension to the shaven backs of 6 rabbits for 24 hours, equivalent to a dose of 4000 mg/kg test substance . During a 14-day observation period, mortality, signs of acute intoxication or local irritation were recorded. Pathological changes were evaluated in all animals. No mortalities occured. No signs of acute intoxication and local irritation were observed. Necropsy revealed no macroscopic and/or organ pathological findings related to test substance exposure. Therefore the dermal LD50 was determined to be > 4000 mg/kg.
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