Registration Dossier
Registration Dossier
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EC number: 205-598-9 | CAS number: 143-29-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Bis(2-(2-butoxyethoxy)ethoxy)methane
- EC Number:
- 205-598-9
- EC Name:
- Bis(2-(2-butoxyethoxy)ethoxy)methane
- Cas Number:
- 143-29-3
- Molecular formula:
- C17H36O6
- IUPAC Name:
- 5,8,11,13,16,19-hexaoxatricosane
- Details on test material:
- - Name of test material (as cited in study report): TP-90B Rubber Chemical
- Analytical purity: no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Francucci Enzo, Rieti, Italy
- Age at study initiation: 9-11 weeks
- Weight at study initiation: 2.9-3.5 kg
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated eye
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- test substance was not washed out.
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- SCORING SYSTEM: Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24-48-72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-48-72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24-48-72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24-48-72 h
- Score:
- 0
- Max. score:
- 4
- Other effects:
- The test substance had a slight irritant effect in the eye 1 hour after instillation.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
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