2-(4-tert-butylbenzyl)propionaldehyde

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline standards with acceptable restrictions (3 animals/sex/dose, no GLP)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Version / remarks:

(limit test)

Deviations:

yes

Remarks:

- 3 animals/sex/dose were employed. Guideline recommends 5/sex/dose.

GLP compliance:

no

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-(4-tert-butylbenzyl)propionaldehyde

EC Number:

201-289-8

EC Name:

2-(4-tert-butylbenzyl)propionaldehyde

Cas Number:

80-54-6

Molecular formula:

C14H20O

IUPAC Name:

3-(4-tert-butylphenyl)-2-methylpropanal

Details on test material:

- Name as cited in document: Lilial
- Analytical purity: 99%
- Batch No.: not reported
- Physical state: liquid

Test animals

Species:

rat

Strain:

other: Sprague Dawley, Wiga

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Diet: Herilian MRH

ENVIRONMENTAL CONDITIONS
- no further details given

Administration / exposure

Type of coverage:

occlusive

Vehicle:

CMC (carboxymethyl cellulose)

Details on dermal exposure:

TEST SITE
- Area of exposure: Back, 50cm2
- % coverage: no data
- Type of wrap if used: no data

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data

TEST MATERIAL
- Amount(s) applied: 2.12 ml/kg bw
- Concentration: 100%

VEHICLE
- Concentration (if solution): 0.5%

Duration of exposure:

not reported

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: 1h, 24h, 48h, day 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weights

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Remarks on result:

other: No mortalities occured within 14 days at a dose of 2000 mg/kg bw

Mortality:

No animal died.

Clinical signs:

other: - Dyspnea, agitation, apathy, staggering, rough fur coat, lacrimation, poor general condition. A questionable reddening of the skin and slight edema was seen after 24 h. After 7 days desquamation was recorded. At the end of the observation period, all s

Gross pathology:

- No adverse pathological effect was observed