Tricyclo[3.3.1.13,7]decane-1-acetic acid, .alpha.-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxy-, (.alpha.S)-

Density

Administrative data

Endpoint:

density

Remarks:

density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental Starting Date: 08 August 2012 Experimental Completion Date: 23 August 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Report date:

2013

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

GLP compliance:

yes

Type of method:

pycnometer method

Test material

Test material information

Constituent 1

Reference substance name:

BMS-528233-01

IUPAC Name:

BMS-528233-01

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

Identification: BMS-528233-01
Description: White powder
BMS Batch Number: 2C80150N
Vendor Batch Number LTBB2S1005
Structure: Please see Attachment 1 of this Summary
Molecular Formula: C17H27NO5
Molecular Weight: 325.41
Purity: >100 %
Expiry Date: 31 January 2015
Storage Conditions: Room temperature, in the dark

Results and discussion

Density

Type:

density

Density:

1 240 kg/m³

Temp.:

21.5 °C

Any other information on results incl. tables

Results

Calibration

The pressure readings and the calculated volume for the reference and sample cells are shown in the following table:

 

Table 3.2

 

Determination	p1	p2	p3	p4	Reference Cell Volume (cm^3)	Sample Cell Volume (cm^3)
1	17.013	6.442	17.024	8.439	90.690	148.818
2	17.025	6.454	17.023	8.438	91.154	149.301
3	17.083	6.475	17.014	8.435	91.044	149.157

 

 

Sample

The pressure readings, calculated volumes and density values obtained for the test item are shown in the following table:

 

Table 3.3

 

Determination	Test	p1	p2	Volume (cm^3)	Density (kg/m^3)	Mean Density (kg/m^3)
1	A	17.020	7.346	29.3	1.24 x 10^3	1.24 x 10^3
	B	17.004	7.338	29.3	1.24 x 10^3
	C	17.003	7.335	29.2	1.24 x 10^3
2	A	16.977	7.496	34.0	1.23 x 10^3	1.24 x 10^3
	B	17.036	7.522	34.0	1.23 x 10^3
	C	16.966	7.487	33.9	1.24 x 10^3

 

Temperature:              21.5 ± 0.5 ºC
Mean density:            1.24 x 10³ kg/m³

Applicant's summary and conclusion

Conclusions:

Please see Conclusion below in the Executive Summary Section.

Executive summary:

The determination was carried out using a gas comparison pycnometer, designed to be compatible with Method A3 Relative Density of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 109 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

        

Conclusion

The density of the test item has been determined to be 1.24 x 10³kg/m³at 21.5 ± 0.5 °C.