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Diss Factsheets
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EC number: 263-454-0 | CAS number: 62202-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Corrosive. Flammable in air at room temperature. According to the Annex VII Standard Information Requirements for REACH, as steps 3 and 4 of the assessment of the skin irritation or skin corrosion endpoint, in vitro tests for skin irritation or corrosion are required. A specific rule for adaptation for the skin irritation /skin corrosion test states that the study(ies) do not need to be conducted if - the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes or – the substance is flammable in air at room temperature.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance is spontaneously flammable in air or in contact with water or moisture at room temperature
- Interpretation of results:
- corrosive
- Remarks:
- Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Corrosive. Thus, exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no in vitro skin irritation and corrosivity studies are required for this substance.
- Executive summary:
Corrosive. Thus, exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no in vitro skin irritation and corrosivity studies are required for this substance.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance is spontaneously flammable in air or in contact with water or moisture at room temperature
- Interpretation of results:
- corrosive
- Remarks:
- Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Corrosive. Thus, exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no in vitro eye irritation studies are required for this substance.
- Executive summary:
Corrosive. Thus, exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no in vitro eye irritation studies are required for this substance.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Corrosive. Flammable in air at room temperature.
Magnesium alkyls are highly reactive both towards oxygen (air) and water as explained below. Almost all magnesium alkyls are infusible solids, however, because of difficulties in handling undiluted magnesium alkyl and the manufacturing processes used, they are exclusively marketed in liquid state (hydrocarbon solutions) and shipped under UN transport class 4.2 (substances liable to spontaneous combustion / pyrophoric liquids) or at least under class 4.3 (substances which in contact with water emit flammable gases). Thus, these in vitro tests are technically not feasible to conduct and are scientifically unjustified.
Magnesium alkyls in general are highly reactive towards oxidizing agents including molecular oxygen, thus reacting spontaneously in air. Neat magnesium alkyls also ignite spontaneously on contact to air and therefore are classified pyrophoric.
Reactions of magnesium alkyls with liquids are in some cases explosion like. Most prominent example is reaction with water, which liberates for short chain alkyls highly flammable gases within seconds (alkyl groups with five carbon atoms and less). But any substance bearing protic hydrogen react in similar fashion, like alcohols, acids (organic and inorganic), etc.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effects on respiratory irritation: highly irritating
Justification for classification or non-classification
Corrosive. Flammable in air at room temperature. According to the Annex VII Standard Information Requirements for REACH, as steps 3 and 4 of the assessment of the skin irritation or skin corrosion endpoint, in vitro tests for skin irritation or corrosion are required. A specific rule for adaptation for the skin irritation /skin corrosion test states that the study(ies) do not need to be conducted if - the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes or – the substance is flammable in air at room temperature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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