Registration Dossier

Administrative data

Description of key information

A LLNA study according to OECD guidelines and GLP principles is available to assess the skin sensitising properties of the substance, showing no skin sensitisation.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

An LLNA study performed according to OECD, EC and EPA test guidelines was performed. Groups of 5 female mice were exposed to 0, 10, 25 and 50% of test substance. Since there was no indication that the test substance elicits an SI = 3 when tested up to 50%, 1,1-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol was considered not to be a skin sensitizer. It was established that the EC3 value (the estimated test substance concentration that will give a SI =3) (if any) exceeds 50%.


Migrated from Short description of key information:
A LLNA study according to OECD guidelines and GLP principles is available to assess the skin sensitising properties of the substance, showing no skin sensitisation.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the results of the LLNA test the substance would not be regarded as a skin sensitizer according to the recommendations made in the test guidelines. It does not have to be classified and has no obligatory labelling requirement for sensitization by contact according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2007) and the Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures.