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Diss Factsheets
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EC number: 237-301-3 | CAS number: 13732-62-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meet basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Induction of Malignant Tumors in Rats by Simultaneous Feeding of Nitrite and Secondary Amines (Induktion maligner Tumoren bei Ratten durch gleichzeitige Verfütterung von Nitrit und sckundärcn Aminen).
- Author:
- Sander J & Bürkle G
- Year:
- 1 969
- Bibliographic source:
- Z. Krebsforsch. 73: 54-66
Materials and methods
- Principles of method if other than guideline:
- The carcinogenic potential of a combination of nitrite and morpholine was assessed.
- GLP compliance:
- no
- Remarks:
- prior to GLP
Test material
- Reference substance name:
- Morpholine
- EC Number:
- 203-815-1
- EC Name:
- Morpholine
- Cas Number:
- 110-91-8
- Molecular formula:
- C4H9NO
- IUPAC Name:
- morpholine
- Details on test material:
- - Name of test material: Morpholine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 120 ± 3 g
- Diet: Altromin
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: Altromin (standard diet)
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 56 Days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
500 mg/kg/d
Basis:
- No. of animals per sex per dose:
- 7 animals
- Control animals:
- yes, plain diet
- Details on study design:
- Post-exposure period: After 270 days had elapsed, all animals of the test group were sacrificed; no further data
Examinations
- Observations and examinations performed and frequency:
- BODY WEIGHT: Yes
- Time schedule for examinations: in regular intervals - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: Yes - Statistics:
- Not specified.
Results and discussion
Results of examinations
- Details on results:
- No animal of the test group and of the control group died within the study period of 56 days.
After 270 days had elapsed, all animals of the test group were sacrificed, the only symptom was moderate adiposis of the liver.
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 500 mg/kg bw/day (nominal)
- Sex:
- female
- Basis for effect level:
- other: liver findings
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
- In a repeated dose toxicity study in Sprague-Dawley rats (Sander & Bürkle, 1969), Morpholine was added to feed for eight weeks. Seven rats took in a daily average of 0.5 g/kg bw. This dosage did not kill the animals. After 270 days had elapsed, the only symptom was moderate adiposis of the liver. Damage caused by subchronic oral intake of Morpholine depended markedly on the individual dose and route of administration. This study is classified as acceptable.
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