Registration Dossier
Registration Dossier
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EC number: 401-670-0 | CAS number: 79456-26-1 ACTF; P-007
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not known whether GLP or not
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 202 (1984)
- Deviations:
- yes
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-chloro-5-trifluoromethyl-2-pyridylamine
- EC Number:
- 401-670-0
- EC Name:
- 3-chloro-5-trifluoromethyl-2-pyridylamine
- Cas Number:
- 79456-26-1
- Molecular formula:
- C6H4ClF3N2
- IUPAC Name:
- 3-chloro-5-(trifluoromethyl)pyridin-2-amine
Constituent 1
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- semi-static
- Total exposure duration:
- 21 d
Test conditions
- Hardness:
- 250 mg CaCO3/l
- pH:
- 7.4 - 9.6
- Dissolved oxygen:
- 4.5 - 8.9 mg/l
- Details on test conditions:
- Magnetic stirring during 72 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 6.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 6.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: parental mortality
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 12.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: parental mortality
- Details on results:
- First brood after 8 days
20% mortality of parents in control
Large variation in pH and disolved oxygen
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 21-day NOEC: 6.2 mg/l (reproduction Daphnia magna)
- Executive summary:
21-day NOEC: 6.2 mg/l (reproduction Daphnia magna)
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