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Diss Factsheets
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EC number: 203-931-2 | CAS number: 112-05-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study performed in 1993.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- The following information is available from the "OPP Pesticide Ecotoxicity Database" home page (https://ecotox.ipmcenters.org/) relating to reliability of the source data:
"The toxicity data input into the database is compiled from actual studies reviewed by EPA in conjunction with pesticide registration or re-registration and studies performed by US EPA, USDA and US FWS laboratories which have been reviewed by Agency biologists and judged acceptable for use in the ecological risk assessment process."
Further details on this study (MRID number: 43065303) were obtained via personal communication with US EPA (reference: T11302) - Qualifier:
- according to guideline
- Guideline:
- EPA OPP 72-2 (Aquatic Invertebrate Acute Toxicity Test)
- Version / remarks:
- Freshwater invertebrate acute; 72-2/850.1010
- Deviations:
- no
- Remarks:
- According to T11302
- GLP compliance:
- yes
- Remarks:
- According to T11302
- Analytical monitoring:
- yes
- Remarks:
- According to T11302
- Details on sampling:
- not available
- Vehicle:
- no
- Remarks:
- No surfactant or dispersant used; no data on solvent use available - according to the guideline validity criteria, any solvent used had to conform with guideline criteria: <= 0.1 mL/L for recommended solvents (OCSPP 850.1000), including a solvent control
- Details on test solutions:
- not available
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain: no data
- Source: no data
- cultured at the test facility, all organisms used originating from the same stock;
- Age at study initiation (mean and range, SD): < 24 h
ACCLIMATION
- Acclimation period: culture condition similar to test conditions; brood daphnids maintained in dilution water at the test temperature for at least 48 hours prior to the start of the test. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- not applicable
- Hardness:
- < 250 mg/L (as CaCO3), no further details available
- Test temperature:
- according to guideline specification, i.e. ca. 20 °C (within 18-22 °C), kept constant during the test within (±) 1 °C.
- pH:
- according to guideline specification, i.e. between limits of 6.0 and 8.5, with a variation during the test of less than 1 pH unit
- Dissolved oxygen:
- >60 % saturation for all concentration levels and the control
- Salinity:
- not applicable
- Conductivity:
- not avialable
- Nominal and measured concentrations:
- At least 5 test item concentrations were used. Further data are not available.
- Details on test conditions:
- A minimum of 20 daphnids was divided into a minimum of 2 replicates, each with >=10 daphnia. Each test vessel contained an equal volume of test solution and an equal number of daphnids. Replicate test vessels were physically separated (experimental unit = test vessel).
Start of the test: by introducing <24-hour old daphnids (from acclimated parents).
Test vessels were loosely covered to reduce the loss of test solution or dilution water due to evaporation.
Light intensity: between 540-1080 lux;
Light regime: according to the guideline, i.e. from 12 hours light:12 hours dark to 16 hours light:8 hours dark;
Observations: immobilization; any abnormal behaviour or appearance;
Feeding: No feeding during test;
Aeration: no; - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 96 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 64-119 mg/L
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 39 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Reported statistics and error estimates:
- 95% confidence interval: 64 mg/L to 119 mg/L
- Validity criteria fulfilled:
- yes
- Remarks:
- based on T11302
- Conclusions:
- 48-h EC50 (Daphnia magna; immobilization): 96 mg/L (mean measured; 95% CI: 64-119 mg/L; EPA OPP, 2000)
- Executive summary:
The acute aquatic toxicity towards the aquatic invertebrate Daphnia magna was assessed in a static test according to EPA OPP 72-2/850.1010 (EPA OPP, 2000). The full study report was not available, but essential data are reported within US EPA "OPP Pesticide Ecotoxicity Database". This database is a reliable source, because according to DB homepage "The toxicity data input into the database is compiled from actual studies reviewed by EPA in conjunction with pesticide registration or re-registration and studies performed by US EPA, USDA and US FWS laboratories which have been reviewed by Agency biologists and judged acceptable for use in the ecological risk assessment process." Additional details were retrieved via personal communication with US EPA. Accordingly, the study was performed without any deviations from the guideline, compliant with GLP. All validity criteria of the guideline were met. During the static study, test item concentrations were analytically verified, and effect concentrations are given based on mean measured values.
The following results were obtained:
EC50 (48 h; static; immobilization; mean measured) = 96 mg/L (95% CI: 64-119 mg/L);
NOEC (48 h; static; immobilization; mean measured) = 39 mg/L
Reference
Description of key information
48-h EC50 (Daphnia magna; immobilization): 96 mg/L (mean measured; 95% CI: 64-119 mg/L; EPA OPP, 2000)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 96 mg/L
Additional information
The acute aquatic toxicity towards the aquatic invertebrate Daphnia magna was assessed in a static test according to EPA OPP 72-2/850.1010 (EPA OPP, 2000). The full study report was not available, but essential data are reported within US EPA "OPP Pesticide Ecotoxicity Database". This database is a reliable source, because according to DB homepage "The toxicity data input into the database is compiled from actual studies reviewed by EPA in conjunction with pesticide registration or re-registration and studies performed by US EPA, USDA and US FWS laboratories which have been reviewed by Agency biologists and judged acceptable for use in the ecological risk assessment process." Additional details were retrieved via personal communication with US EPA. Accordingly, the study was performed without any deviations from the guideline, compliant with GLP. All validity criteria of the guideline were met. During the static study, test item concentrations were analytically verified, and effect concentrations are given based on mean measured values.
The following results were obtained:
EC50 (48 h; static; immobilization; mean measured) = 96 mg/L (95% CI: 64-119 mg/L);
NOEC (48 h; static; immobilization; mean measured) = 39 mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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