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EC number: 222-598-4 | CAS number: 3547-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The NOEL for systemic toxicity from a 90-day dietary toxicity study on 2-(octylthio)ethanol is 0.4% in the diet, based on decreased terminal body weights, and increased liver and kidney weights.
The NOEL for systemic toxicity from a 21-day dermal toxicity study on 2-(octylthio)ethanol is at least 200 mg/kg. The NOEL for dermal irritation is 50 mg/kg.
Key value for chemical safety assessment
Additional information
In a 90 -day feeding study, male and female Sprague-Dawley rats were fed 2-(octylthio)ethanol in their diet at concentrations of 0, 0.08, 0.4 or 2%. Terminal body weights were reduced in the 2% dietary dose group (males, 8.6%; females, 10%). Food consumption was also slightly reduced in the 2% dietary dose group. In the 2% dose group, terminal liver weights were increased (males, 35%; females, 38%); terminal liver weights relative to body weights were increased (males, 36%; females, 53%); and kidney weights relative to body weights were increased (males, 12%; females, 18%). There were no treatment-related histopathologic effects. The NOEL for this study is 0.4% 2-(octylthio)ethanol in the diet (Powers, M.B., 1961).
In a 21-day dermal toxicity study, New Zealand white rabbits (5/sex/dose) were given repeated dermal applications of technical hydroxyethyl octyl sulfide (100%) in corn oil at doses of 50, 100 or 200 mg/kg, 6 hours/day, 7 days/week for 21 days; the vehicle control group (5/sex) received corn oil only on the same regimen. Treatment had no adverse effect on survival, clinical signs, mean body weights, body weight gain, food consumption, hematology, clinical chemistry, organ weights or gross histopathology. Treatment-related skin reactions were confined mainly to a proportion of animals receiving 100 or 200 mg/kg/day. Dermal reactions included: skin wrinkling in 1 male at 200 mg/kg/day; desquamation in 1 female at the vehicle control, 1 male and 1 female at 50 mg/kg/day, in 3 males and 2 females at 100 mg/kg/day, and in 5 males and 4 females at 200 mg/kg/day; and moderate to severe erythema usually in combination with moderate edema in 1 male and 1 female at the vehicle control and at 50 mg/kg/day, in 4 males and 0 females at 100 mg/kg/day and in 4 males and 2 females at 200 mg/kg/day. Based on these results, for dermal irritation the NOEL was 50 mg/kg/day and the LOEL was 100 mg/kg/day. For systemic toxicity the NOEL was > 200 mg/kg/day; a LOEL was not established (US EPA, 1995).
Justification for classification or non-classification
Based on the available repeat dose toxicity data on 2-(octylthiol)ethanol, no classification under DSD or GHS/CLP is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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