Registration Dossier
Registration Dossier
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EC number: 203-308-5 | CAS number: 105-55-5
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Embryotoxicity of industrial chemicals on the chicken embryo: Thiourea derivatives.
- Author:
- Korhonen A., Hemminki K, Vainio H.
- Year:
- 1 982
- Bibliographic source:
- Acta pharmacol. et toxicol., 1982; 51: 38-44.
- Reference Type:
- publication
- Title:
- Toxicity of rubber chemicals towards three-day chicken embryos
- Author:
- KORHONEN-A, HEMMINKI-K, VAINIO-H
- Year:
- 1 983
- Bibliographic source:
- SCAND-J-WORK-ENVIRON-HEALTH 9 115-119
Materials and methods
- Type of study / information:
- in vitro test, on chicken embryo
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3-diethyl-2-thiourea
- EC Number:
- 203-308-5
- EC Name:
- 1,3-diethyl-2-thiourea
- Cas Number:
- 105-55-5
- Molecular formula:
- C5H12N2S
- IUPAC Name:
- 1,3-diethyl-2-thiourea
Constituent 1
Results and discussion
Any other information on results incl. tables
EMBRYOTOXIC EFFECTS:
- Test substance mainly caused early deaths and a dose-response was observed.
Rate of early deaths =
. 3 % of embryos at 1.0 µmol/egg,
. 77 % at 4.0 µmol/egg,
. 100 % at the highest doses (i.e. at 6.0 and 8.0 µmol/egg).
- No embryo that died late was observed as malformed.
- 3 to 7 % of survivors were malformed at the lowest doses (from 1.0 to 4.0 µmol/egg).
- 2 to 7 % of the late dead were not malformed at the lowest doses (from 1.0 to 3.0 µmol/egg).
CALCULATED PARAMETERS:
. ED50 = 3.1 µmol/egg
. LD 50 for total mortality = 3.3 µmol/egg
. LD50 for dead not malformed = 3.3 µmol/egg
. LD50 for early deaths = 3.4 µmol/egg
MAIN INDUCED MALFORMATIONS:
- small eye cup (17% of malformated survuivals)
- lack of lids and cornea or parts of them (50% of malformated survivals)
- open coelom (50% of malformated survivals)
- defects of back and neck (33% of malformated survivals).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
