Registration Dossier
Registration Dossier
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EC number: 219-417-6 | CAS number: 2432-99-7
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
A calculated value is available: logKow = -0.16.
In order to test the applicability of the model for the substance of interest and so to validate the model for aminoacids, logKow of other aminoacids have been calculated using the EPIWIN program (KowWin v1.67 fragment description) and compared with the experimental data reported in the same model.
The results are as follows :
For 6 aminohexanoic acid (60-32-2): logKow (estimated) = - 2.62 logKow (experimental) : -2.95
For 8-aminooctanoic acid (1002-57-9): logKow (estimated) = -1.64 Experimental logKow = - 2,55
The estimated logKow values are similar to the experimental data reported in the same model, showing that the model is applicable to this type of aminoacids.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.16
- at the temperature of:
- 20 °C
Additional information
As the applicability of the EPIWIN program (KowWin v1.67) for the estimation of log Kow values of aminoacids has been demonstrated, this calculated value is considered acceptable and its reliability is considered as "2".
Considering the log Kow value of -0.16, 11-aminoundecanoic acid has a low potential for bioaccumulation.
According to the Guidance on information requirements and chemical safety assessment Chapter R.7a: Endpoint specific guidance (ECHA, 2008), the impact of errors on model predictions for a logKow value below 1 is usually less critical. Moreover, the value estimated is outside the applicability range of the reverse phase HPLC method (OECD GL 117) and very closed to the lowest value of the applicability range of the shake flask method (OECD GL 107). Therefore, it is considered that an experimental study is not needed.
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