Registration Dossier
Registration Dossier
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EC number: 225-791-1 | CAS number: 5080-22-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Two acute studies are available on the toxicity of IPHA to aquatic invertebrates. The first acute study (2004) was conducted on the freshwater invertebrate Daphnia magna and the second acute study (2011) was conducted on the marine invertebrate Acartia tonsa. The Daphnia study was conducted according to the OECD 202 guideline and the Acartia study was conducted according to the ISO TC147/SC5/WG2. No analytical verification was conducted on either test, thus endpoint values were based on nominal exposure values.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 201 mg/L
Marine water invertebrates
Marine water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 1.4 mg/L
Additional information
One acute study with a freshwater invertebrate and one acute study with a marine invertebrate is available. For the freshwater compartment, a static-renewal study with Daphnia magna (<1 day old) is available (The Dow Chemical Company, 2004). The study was conducted according to the OECD 202 guideline (Daphnia sp., Acute Immobilisation Test). The 48 -h EC50 was 201 mg/l and the 48 -h NOEC was 77.8 mg/L, based on nominal concentrations. For the marine compartment, a static acute study with the marine invertebrate Acartia tonsa is available (Harlan Laboratories, Ltd., 2011). The study was conducted according to the ISO TC147/SC5/WG2 guideline. The 48 -h LC50 was determined to be 1.4 mg/L and the 48 -h NOEC was 0.56 mg/L, based on nominal concentrations. This study produced the most sensitive endpoint for aquatic invertebrates, as well as the most sensitive endpoint overall.
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