Registration Dossier
Registration Dossier
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EC number: 605-830-2 | CAS number: 178671-69-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- In a GLP guideline study (according to OECD TG 406) the skin sensitisation
potential of the test article was assessed in a guinea pig maximization
test with a group of 10 female animals (BASF, 1998). Ten additional
animals (two groups of five animals each) served as controls. The animals
were treated intradermally and epicutaneously (5% and 50%, respectively)
in the induction period followed by an epicutaneous challenge (10%). None
of the animals of the test group and no animal of the control groups
showed skin findings 24 and 48 hours after the challenge. The sensitivity
of the used animal strain was tested before with a positive control
substance (not performed during this study). Based on the results of this
study it was concluded that the test article does not have a sensitizing
effect on the skin of the guinea pig in the Maximization Test under the
test conditions chosen.
Migrated from Short description of key information:
No skin sensitization potential of the test substance was observed in a guinea pig maximization test.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
-No classification for skin sensitization required
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008 (last amended by EC/286/2008 (2011-03-10)):
-No classification for skin sensitization required
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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