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EC number: 289-296-2 | CAS number: 87061-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 9th March 1999 to 12th March 1999
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The work was undertaken in 1999 and was not conducted to GLP although a statement of authentication is included. The study was not conducted to a recognised guideline as none are known to exist for this type of study, but was conducted in accordance with the method published in 1974 by Morikawa et al, a full description of which is included within the report. The results are not well reported being restricted to a summary table that does not describe the effects on individual animals and thus cannot be used to assess the dermal irritation potential of the substance in accordance with appropriate criteria. Neither the batch number nor the purity of the substance is reported in the study and the study was conducted up to a maximum concentration of 40% of the nominal concentration of the test material. As the substance was not tested up to its full concentration, and that the results are not adequately reported the study, it cannot be considered to be reliable in assessing the dermal irritation potential of the test material.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
- Type of study / information:
- Phototoxic Potential:
The objective of the study was to determine the skin irritancy potential of the test material with and without UV radiation.
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The phototoxic potential of the test material was assessed in Hartley albino guinea pigs. The test material was applied to the skin at concentrations of 40, 20, 10 and 5 % (w/w) on either side of the test animal. After application, one side was covered with foil, the other was irradiated. The test sites were observed 24, 48 and 72 hours after application and the dermal reactions recorded. The method was based on the study Morikawa F et al (1974) University of Tokyo Press, Tokyo Japan: 529-527.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-[[5-methyl-2-(1-methylethyl)cyclohexyl]oxy]propane-1,2-diol
- EC Number:
- 289-296-2
- EC Name:
- 3-[[5-methyl-2-(1-methylethyl)cyclohexyl]oxy]propane-1,2-diol
- Cas Number:
- 87061-04-9
- Molecular formula:
- C13H26O3
- IUPAC Name:
- 3-{[5-methyl-2-(propan-2-yl)cyclohexyl]oxy}propane-1,2-diol
- Test material form:
- liquid
Constituent 1
Results and discussion
Any other information on results incl. tables
Table 2: Summary of results
Concentration (%) |
Dermal Irritation (non-irradiated) |
Dermal Irritation Irradiated |
||||||
40 |
20 |
10 |
5 |
40 |
20 |
10 |
5 |
|
Primary Irritation Index |
0.13 |
0 |
0 |
0 |
0.75 |
0.38 |
0 |
0 |
Number of reactions |
1/8 |
0/8 |
0/8 |
0/8 |
6/8 |
3/8 |
0/8 |
0/8 |
Classification |
± |
- |
- |
- |
+ |
+ |
- |
- |
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the test, it was concluded that the test material was not a primary skin irritant up to a concentration of 20 % and non-phototoxic up to a concentration of 10 % in the Hartley guinea pig.
- Executive summary:
The phototoxic potential of the test material was assessed in Hartley albino guinea pigs. The test material was applied to the skin at concentrations of 40, 20, 10 and 5 % (w/w) on either side of the test animal. After application, one side was covered with foil, the other was irradiated. The test sites were observed 24, 48 and 72 hours after application and the dermal reactions recorded. The method was based on the study Morikawa F et al (1974) University of Tokyo Press, Tokyo Japan: 529-527. Under the conditions of the test, it was concluded that the test material was not a primary skin irritant up to a concentration of 20 % and non-phototoxic up to a concentration of 10 % in the Hartley guinea pig.
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