Registration Dossier
Registration Dossier
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EC number: 418-480-9 | CAS number: 138526-69-9 1-BROM-3,4,5-TRIFLUORBENZOL; 1-BROMO-3,4,5-TRIFLUOROBENZENE
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01.08.1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Directive 92/69/EEC
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 130 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- >= 5.8 - <= 6
- Details on results:
- The preliminary test determined the water solubility to be approximately 0.277 g/L.
- Conclusions:
- The water solubility of the test item was determined to be 130 mg/L at 20 °C and pH 6.
- Executive summary:
The water solubility was determined according to Directive 92/69/EEC method A.6 using the shake flask method with HPLC analysis.A preliminary test was undertaken to determine the approximate water solubility. Based on the preliminary result, aliquots of test material, were weighed into three separate flasks. After addition of glass double-distilled water to the flasks, they were shaken at approximately 30 °C and, after standing at 20 °C for a period of not less than 24 hours, the contents of the flasks were filtered and the concentrations determined by HPLC.The water solubility of the test substance was determined to be 130 mg/L at 20 °C and pH = 6.
Reference
Sample number |
Time shaken at |
Time held at |
Concentration (g/L) |
Solution pH |
1 |
24 |
25 |
0.132 |
5.8 |
2 |
48 |
25 |
0.126 |
6.0 |
3 |
72 |
25 |
0.132 |
6.0 |
Mean concentration = 0.130 g/L = 130 mg/L
Range = 0.126 - 0.132 g/L
Description of key information
The water solubility of the test item was determined to be 130 mg/L at 20 °C and pH 6 (reference 4.8-1).
Key value for chemical safety assessment
- Water solubility:
- 130 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility was determined according to Directive 92/69/EEC method A.6 using the shake flask method with HPLC analysis. A preliminary test was undertaken to determine the approximate water solubility. Based on the preliminary result, aliquots of test material, were weighed into three separate flasks. After addition of glass double-distilled water to the flasks, they were shaken at approximately 30 °C and, after standing at 20 °C for a period of not less than 24 hours, the contents of the flasks were filtered and the concentrations determined by HPLC. The water solubility of the test substance was determined to be 130 mg/L at 20 °C and pH = 6.
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