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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 291-826-2 | CAS number: 90480-88-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening test, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- February 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The substance is a multi-constituent substance of limited solubility. CLP classification is available for the individual components of the substance via REACH Annex VI harmonised classifications, REACH Registration dossiers or notifications to the CLP inventory. As such, it is deemed inappropriate to conduct additional testing on the reaction mass subject to this registration when the results may be predicted on the basis of the components themselves. Validated QSAR calculation method, using BIOWIN v4.10 model from the EPA ECOSAR Suite. A QPRF is attached. The Biodegradation Probability Program (BIOWIN) estimates the probability for the rapid aerobic biodegradation of an organic chemical in the presence of mixed populations of environmental microorganisms. Estimates are based upon fragment constants that were developed using multiple linear and non-linear regression analyses. Experimental biodegradation data for the multiple linear and non-linear regressions were obtained from Syracuse Research Corporation's (SRC) data base of evaluated biodegradation data. This system is recognised in ECHA Guidance document CHAPTER R.6 – QSARS AND GROUPING OF CHEMICALS, Pg 47
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Validated QSAR calculation method, using BIOWIN v4.10 model from the EPA ECOSAR Suite. A QPRF is attached. The Biodegradation Probability Program (BIOWIN) estimates the probability for the rapid aerobic biodegradation of an organic chemical in the presence of mixed populations of environmental microorganisms. Estimates are based upon fragment constants that were developed using multiple linear and non-linear regression analyses. Experimental biodegradation data for the multiple linear and non-linear regressions were obtained from Syracuse Research Corporation's (SRC) data base of evaluated biodegradation data.
- GLP compliance:
- no
- Specific details on test material used for the study:
- Not applicable – QSAR Assessment
- Oxygen conditions:
- other: Not applicable – QSAR Assessment
- Inoculum or test system:
- other: Not applicable – QSAR Assessment
- Details on inoculum:
- Not applicable – QSAR Assessment
- Details on study design:
- Not applicable – QSAR Assessment
- Preliminary study:
- Not applicable – QSAR Assessment
- Test performance:
- Not applicable – QSAR Assessment
- Key result
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Details on results:
- The substance is a multi-constituent substance of limited solubility. CLP classification is available for the individual components of the substance via REACH Annex VI harmonised classifications, REACH Registration dossiers or notifications to the CLP inventory. As such, it is deemed inappropriate to conduct additional testing on the reaction mass subject to this registration when the results may be predicted on the basis of the components themselves. QSAR assessment using US EPA On-Line EPI Suite™ BIOWIN v4.10 model assessment of ready biodegradation is utilised to assess each component with the exception of phenol (which carries significant data already), with the associated range of results reported. The reaction mass is deemed to be “not readily biodegradable. On the basis of an average value, Environment Category Chronic 2: H411: Toxic to aquatic life with long lasting effects is assigned.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The substance is a multi-constituent substance of limited solubility. CLP classification is available for the individual components of the substance via REACH Annex VI harmonised classifications, REACH Registration dossiers or notifications to the CLP inventory. As such, it is deemed inappropriate to conduct additional testing on the reaction mass subject to this registration when the results may be predicted on the basis of the components themselves. QSAR assessment using US EPA On-Line EPI Suite™ BIOWIN v4.10 model assessment of ready biodegradation is utilised to assess each component with the exception of phenol (which carries significant data already), with the associated range of results reported. The reaction mass is deemed to be “not readily biodegradable. On the basis of an average value, Environment Category Chronic 2: H411: Toxic to aquatic life with long lasting effects is assigned.
- Executive summary:
The substance is a multi-constituent substance of limited solubility. CLP classification is available for the individual components of the substance via REACH Annex VI harmonised classifications, REACH Registration dossiers or notifications to the CLP inventory. As such, it is deemed inappropriate to conduct additional testing on the reaction mass subject to this registration when the results may be predicted on the basis of the components themselves. QSAR assessment using US EPA On-Line EPI Suite™ BIOWIN v4.10 model assessment of ready biodegradation is utilised to assess each component with the exception of phenol (which carries significant data already), with the associated range of results reported. The reaction mass is deemed to be “not readily biodegradable. On the basis of an average value, Environment Category Chronic 2: H411: Toxic to aquatic life with long lasting effects is assigned.
Reference
Results for each component, utilising the BIOWIN v4.10 model are as follows:
Chemical name |
SMILES |
READY BIODEGRADATION |
2-isopropylphenol EC no.: 201-852-8 |
CC(C)c1ccccc1O |
Not biodegradable. |
Phenol EC no.: 203-632-7 |
Oc1ccccc1 |
Degradation rates > 70 % in < 10 d. (taken from REACH registration) |
p-isopropylphenol EC no.: 202-798-8 |
CC(C)c1ccc(O)cc1 |
Not biodegradable. |
2,4-diisopropylphenol EC no.: 220-906-1 |
CC(C)c1ccc(O)c(c1)C(C)C |
Not biodegradable. |
Refer to appended output below.
Description of key information
The substance is a multi-constituent substance of limited solubility. CLP classification is available for the individual components of the substance via REACH Annex VI harmonised classifications, REACH Registration dossiers or notifications to the CLP inventory. As such, it is deemed inappropriate to conduct additional testing on the reaction mass subject to this registration when the results may be predicted on the basis of the components themselves. QSAR assessment using US EPA On-Line EPI Suite™ BIOWIN v4.10 model assessment of ready biodegradation is utilised to assess each component with the exception of phenol (which carries significant data already), with the associated range of results reported. The reaction mass is deemed to be “not readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
On the basis of an average value,Environment Category Chronic 2: H411: Toxic to aquatic life with long lasting effects is assigned.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.