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EC number: 428-100-3 | CAS number: 94239-04-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Substance ID: F6TF
Lot #: R646899
Purity: 99.5% - Radiolabelling:
- no
- Analytical monitoring:
- no
- Buffers:
- - pH: 4
- Composition of buffer: 4.0 mL of 0.1 M sodium hydroxide and 10.21 g of potassium hydrogen phthalate (MW 204.23) made up to 1000 mL with deionised water
- pH: 7
- Composition of buffer: 290 mL of 0.1 M sodium hydroxide and 6.8 g of potassium dihydrogen orthophosphate (MW 136.09) made up to 1000 mL with deionised water
- pH: 9
- Composition of buffer: 46 mL 0.1 M HCl and 4.78 g borax (Na2B4O7.10H2O, MW 381.37) made up to 1000 mL with deionised water - Details on test conditions:
- Preparation of Test Solutions: Buffer solutions were prepared as described above. These buffer solutions were sterilised by autoclaving and subsequently de-oxygenated by bubbling with helium for approximately 5 minutes.
The concentration of the test substance in the test solutions was a nominal 0.90 mg/L. The test solutions were prepared by the addition of an aliquot (100 µL) of a stock solution (900 mg/L) prepared in methanol, to a known volume of the appropriate buffer solution. Due to the volatile nature of the test substance, sacrificial vessels were used for each sampling point. The vessels were 5 mL micro-reaction vessels with PTFE septa. Nine aliquots of each solution were put into the vessels, which had been covered with aluminium foil to exclude light. The pH of the bulk stock solution was recorded using a calibrated meter. All of the vials were put into an oscillating water bath, previously set to 50°C.
A preliminary test was performed on the test substance at 50 ± 0.5°C at pH 4, 7 and 9 in triplicate. If at any pH, less than 10% of the test substance was hydrolysed after 5 days, then it was considered hydrolytically stable under environmental conditions (i.e. estimated half life being ≥ 1 year at 25°C).
Samples from each flask were analysed at time 0, 2.4 hours and 5 days. The pH of the buffered solutions were measured at time 0, 2.4 hours and 5 days. The temperature in the water bath was measured at intervals throughout the study. - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 0.9 - <= 0.94 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 0.88 - <= 93 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 0.89 - <= 0.96 mg/L
- Number of replicates:
- 3
- Preliminary study:
- Hydrolysis was <10% after 5 days at pH 4, 7 and 9 and indicated that at these pHs the test substance could be considered hydrolytic ally stable under environmental conditions (i.e. estimated half life being ≥1 year at 25°C). Consequently, no additional testing was carried out.
- % Recovery:
- 96
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 92
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 98
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Details on results:
- Preliminary Test: Hydrolysis was <10% after 5 days at pH 4, 7 and 9 and indicated that at these pHs the test substance could be considered hydrolytically stable under environmental conditions (i.e. estimated half life ≥ 1 year at 25ºC). No further work on a definitive test was carried out in line with the guidelines.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Hydrolysis was <10% after 5 days at pH 4, 7 and 9 and indicated that at these pHs the test substance could be considered hydrolytically stable under environmental conditions (i.e. estimated half life ≥ 1 year at 25 ºC).
- Executive summary:
A preliminary test was performed on the test substance at approximately 50ºC at pH 4, 7 and 9 in triplicate. Hydrolysis was <10% after 5 days at pH 4, 7 and 9 and indicated that at these pHs the test substance could be considered hydrolytically stable under environmental conditions (i.e. estimated half life ≥1 year at 25 ºC). No further work on a definitive test was carried out in line with the guidelines.
Reference
pH |
Flask |
Time 0 |
2.4 hrs |
5 days |
||||
Measured Concentration (mg/L) |
% Nominal |
Measured Concentration (mg/L) |
% Nominal |
Measured Concentration (mg/L) |
% Nominal |
% Hydrolysis |
||
4 |
1 |
0.90 |
100 |
0.81 |
90 |
0.84 |
93 |
6.7 |
4 |
2 |
0.91 |
101 |
0.88 |
98 |
0.88 |
98 |
3.3 |
4 |
3 |
0.94 |
104 |
0.89 |
99 |
0.87 |
97 |
7.4 |
4 |
average |
0.92 |
102 |
0.86 |
96 |
0.86 |
96 |
5.8 |
7 |
1 |
0.88 |
98 |
0.87 |
97 |
0.82 |
91 |
6.8 |
7 |
2 |
0.93 |
103 |
0.91 |
101 |
0.84 |
93 |
9.7 |
7 |
3 |
0.93 |
103 |
0.92 |
102 |
0.84 |
93 |
9.7 |
7 |
average |
0.91 |
101 |
0.90 |
100 |
0.83 |
92 |
8.8 |
9 |
1 |
0.89 |
99 |
0.90 |
100 |
0.93 |
103 |
-4.5 |
9 |
2 |
0.93 |
103 |
0.90 |
100 |
0.86 |
96 |
7.5 |
9 |
3 |
0.96 |
107 |
0.94 |
104 |
0.86 |
96 |
10.4 |
9 |
average |
0.93 |
103 |
0.91 |
101 |
0.88 |
98 |
4.7 |
Description of key information
Hydrolysis was <10% after 5 days at pH 4, 7 and 9 indicating that the test substance could be considered hydrolytically stable under environmental conditions (estimated half life ≥ 1 year at 25 ºC).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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