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EC number: 259-509-3 | CAS number: 55172-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 ≥ 100 till ≤ 300 mg/kg bw
Acute dermal toxicity: derogation statement included; according to SIAR 2008 an LD50 > 2000 mg/kg was stated in the NIAR report 2008
Acute inhalation toxicity: LC50 > 1 mg/L.
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Acute oral toxicity
There are two reliable studies for acute oral toxicity testing (Borzelleca_ 1988 and Tardiff 1980). Both studies were used for weight of evidence. The study performed by Borzelleca in 1988 leads to an LD50 >100 and <300 mg/kg bw whereas the study conducted by Tardiff 1980 results in an LD50 of 300 mg/kg bw. Taken both studies into consideration for classification an LD50 ≤ 300 mg BaCl2/kg bw required a classification and labelling as "acute tox 3"; H301 (toxic if swallowed) according to GHS.
Specific target organ toxicant (STOT) – single exposure: oral
The classification criteria according to regulation (EC) 1272/2008 as specific target organ toxicant (STOT) – single exposure, oral are not met since no reversible or irreversible adverse health effects were observed immediately or delayed after exposure and no effects were observed at the guidance value, oral for a Category 1 classification of 300 mg/kg bw and at the guidance value, oral for a Category 2 classification of 2000 mg/kg bw in addition to this effects which were responsible for the death of the animals. No classification required.
Acute dermal toxicity
According to the SIAR 27 prepared for barium chloride, an acute dermal toxicity study on barium chloride was conducted according to OECD TG 402, in compliance with GLP. In this study, the dermal LD50 was greater than 2000 mg BaCl2/kg bw in rats. It is note here that the primary data could not be made available by the registrant but using the secondary information no classification according to regulation (EC) 1272/2008 will be necessary for barium chloride.
Acute inhalation toxicity
There is only one study on acute toxicity via inhalation available. This study was performed with a limit concentration of 1.1 mg/L barium chloride dihydrate which relates to a concentration of 0.94 mg/L barium chloride. One out of ten animals died within the observation period. Due to animal welfare reasons, it was decided not to perform a full test with 5 concentrations at higher concentration. Instead, since according to regulation (EC) 1272/2008 the threshold value for LC50is >= 1 mg/L, it can reasonably be stated that the LC50of barium chloride is > 1 mg/L and therefore a classification and labelling of barium chloride as "acute tox. 4"; H332 (harmful via inhalation) according to GHS is required.
Specific target organ toxicant (STOT) – single exposure: inhalation
The classification criteria according to regulation (EC) 1272/2008 as specific target organ toxicant (STOT) – single exposure, inhalation are not met since no reversible or irreversible adverse health effects were observed immediately or delayed after exposure and no effects were observed at the guidance value, inhalation for a Category 1 classification of <= 1 mg/L/4h and at the guidance value, inhalation for a Category 2 <= 5 mg/L/4h - > 1 mg/L/4h. No additional classification required.
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