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EC number: 247-832-2 | CAS number: 26591-72-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08.09.2011-17.04.2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 431; OECD 439
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-methyl-1-vinyl-1H-imidazolium methyl sulphate
- EC Number:
- 247-832-2
- EC Name:
- 3-methyl-1-vinyl-1H-imidazolium methyl sulphate
- Cas Number:
- 26591-72-0
- Molecular formula:
- C6H9N2.CH3O4S
- IUPAC Name:
- 1-ethenyl-3-methyl-1H-imidazol-3-ium methyl sulfate
- Details on test material:
- - Name of test material (as cited in study report): 3-Methyl-1-vinyl-1 H-imidazolium methyl sulfate
- Physical state: solid
- Analytical purity: 99.97 area-%
- Lot/batch No.: 77761968E0
- Expiration date of the lot/batch:
- Stability under test conditions: The stability under storage conditions over the study period was guaranteed by the sponsor, and the sponsor holds this responsibility.
- Other: Test substance number: 11/0584-1
Constituent 1
Test animals
- Species:
- other: human reconstructed epidermis
- Strain:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- not applicable
Test system
- Type of coverage:
- other: not applicable
- Preparation of test site:
- other: not applicable
- Vehicle:
- other: Highly de-ionized water (corrosion test); PBS, sterile (irritation test)
- Controls:
- other: not applicable
- Amount / concentration applied:
- The test substance was applied undiluted.
- Duration of treatment / exposure:
- corrosion test: 3 min and 1 hour
irritation test: 1 hour - Observation period:
- corrosion test: 0 hours (The assay medium was replaced by MTT solution after treatment and tissues were incubated for 3 hours.)
irritation test: 42 hours (After rinsing, tissue were incubated at 37°C for 24 hours in medium. After 24 hours tissues were once again transferred into fresh medium and incubated for additional 18 hours. Afterwards, medium was replaced by MTT solution for the viability testing) - Number of animals:
- Corrosion test: 2 tissues
Irritation test: 3 tissues - Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): The tissues were washed with PBS to remove residual test material
SCORING SYSTEM:
Corrosive potential of the test materials is predicted from the mean relative tissue viabilities obtained after 3 min treatment compared to the negative control tissues concurrently treated with highly de-ionized water
Mean tissue viability (% of negative control)
3 min: < 50 = corrosive
3 min: ≥ 50 and 1 hour: < 15 = corrosive
3 min: ≥ 50 and 1 hour: ≥ 15 = non-corrosive
Although the method is not finally validated for categorizing the severity of corrosivity according to certain classification and labeling systems, it is suggested to use the most stringent category for test substances leading to viabilities below 50% after 3 min treatment.
Irritant potential of the test materials is predicted from the mean relative tissue viabilities after 1 hour with a post-incubation time of 42 hours compared to the negative control tissues concurrently treated with sterile PBS. A chemical is considered as "irritant", if the mean relative tissue viability with a test material is less than or equal to 50%.
Mean tissue viability (% of negative control)
≤ 50 = irritant
> 50 = non-irritant
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: other: mean OD570 values (as measures of the viability in % compared to control) test item, corrosion test
- Value:
- 97 - 102
- Remarks on result:
- other:
- Remarks:
- Basis: mean 2 tissues. Time point: 3 min or 1 hour. Remarks: Corrosion test: Mean tissue viability (% of negative control): 3 min: < 50 = corrosive; 3 min: ≥ 50 and 1 hour: < 15 = corrosive; 3 min: ≥ 50 and 1 hour: ≥ 15 = non-corrosive . (migrated information)
- Irritation / corrosion parameter:
- other: other: mean OD570 values (as measures of the viability in % compared to control) test item, irritation test
- Value:
- 118
- Remarks on result:
- other:
- Remarks:
- Basis: mean 3 tissues. Time point: 42 hours. Remarks: Irritation test: Mean tissue viability (% of negative control) ≤ 50 = irritant; > 50 = non-irritant . (migrated information)
Any other information on results incl. tables
Corrosion test data after 3 min
Test substance | Mean OD 570 | Viability [% of negative control] |
Negative control | 1.87 | 100 |
11/0584 -1 | 1.818 | 97 |
Positive control | 0.244 | 13 |
Corrosion test data after 1 hour
Test substance | Mean OD 570 | Viability [% of negative control] |
Negative control | 1.709 | 100 |
11/0013-1 | 1.741 | 102 |
Positive control | 0.192 | 11 |
Irritation data
Test substance | Mean OD 570 | Viability [% of negative control] |
Negative control | 1.711 | 100 |
11/0013-1 | 2.026 | 118 |
Positive control | 0.095 | 6 |
The tissue viability is calculated as the quotient of the mean OD570 and the respecitve OD570 of the negative control (in percent). Acceptance criteria for the positive control (corrosion test: viability < 30% and irritation test: viability < 20%) were reached in both tests. Corrosive potential of the test materials is predicted from the mean relative tissue viabilities obtained after 3 min treatment compared to the negative control tissues concurrently treated with highly de-ionized water. A chemical is considered as "corrosive", if the mean relative tissue viability after 3 min treatment with a test material is decreased below 50%. In addition, those materials with a viability of ≥ 50% after 3 min treatment are considered as "corrosive" if the mean relative tissue viability after 1 hour treatment with a test material is decreased below 15%.
Irritant potential of the test materials is predicted from the mean relative tissue viabilities compared to the negative control tissues concurrently treated with sterile PBS. A chemical is considered as "irritant", if the mean relative tissue viability with a test material is less than or equal to 50%.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
The potential of 3-Methyl-1-vinyl-1 H-imidazolium methyl sulfate to cause dermal corrosion/irritation was assessed by a single topical application of the test substance to a reconstructed three dimensional human epidermis model (EpiDerm™). Because the viscous test substance could not be applied with a pipette or sharp spoon, a metal pin was covered with about 122 mg of the undiluted test substance. For the corrosion test two EpiDerm™ tissue samples were incubated with the test substance for 3 minutes and 1 hour, respectively. The irritation test was performed with three EpiDerm™ tissue samples, which were incubated with the test substance for 1 hour followed by a 42-hours post-incubation period. Tissue destruction was determined by measuring the metabolic activity of the tissue after exposure/post-incubation using a colorimetric test. The reduction of mitochondrial dehydrogenase activity, measured by reduced formazan production after incubation with a tetrazolium salt (MTT) was chosen as endpoint. The formazan production of the testsubstance treated epidermal tissues is compared to that of negative control tissues. The quotient of the values indicates the relative tissue viability. The EpiDerm™ skin corrosivity/irritation test showed the following results: The test substance is not able to reduce MTT directly. Corrosion test: The mean viability of the test-substance treated tissues determined after an exposure period of 3 minutes was 97%, and it was 102% after an exposure period of 1 hour. Irritation test: The mean viability of the test-substance treated tissues determined after an exposure period of 1 hour with about 42 hours post-incubation was 118%. Based on the observed results and applying the evaluation criteria it was concluded, that 3-Methyl-1-vinyl-1 H-imidazolium methyl sulfate does not show a skin irritation potential in the EpiDerm™ skin corrosion/irritation test under the test conditions chosen.
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