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Diss Factsheets
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EC number: 246-680-4 | CAS number: 25155-30-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: published data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicologic studies with branched and linear alkyl benzene sulfonates in rats
- Author:
- Oser BL and Morgareidge K
- Year:
- 1 965
- Bibliographic source:
- Toxicology and applied phamacology 7, 819-825
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Hagan, EC (1959). Acute toxicity. In: Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics. pp. 17-25. Assoc. of Food and Drug Officials of the US, Bureau of Food and Drugs, Texas State Dept. of Health, Austin, Texas.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Benzenesulfonic acid, alkyl derivs.
- Cas Number:
- 42615-29-2
- IUPAC Name:
- Benzenesulfonic acid, alkyl derivs.
- Test material form:
- solid: compact
- Details on test material:
- LAS had a nominal chain length of 12 carbon atoms (range C9-C15) and an average molecular weight of 346.
(Benzenesulphonic acid, linear alkyl) (C9-C15), purity 39.5% (sodium sulphate 8.8%, water 50.9 %, free alkali (NaOH) 0.05%, unidentified 0.64%)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: FDRL strain(Wistar-derived)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- young adult rats : FDRL strain (Wistar-derived)They were fasted overnight before this test.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- 10% and 40 % dispersions of the samles were prepared in distilled water and administered intragastrically.
- Doses:
- 10% and 40% dispersion of LAS sample at dosages of 0.6 and 1.58 g/kg.
- No. of animals per sex per dose:
- 3
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations for behaviour, appearance and survival were made daily; weighings were performed on days 0, 7, and 14
- Necropsy of survivors performed: yes - Statistics:
- LD50 calculated by the method of Miller, LC, and Tainter, ML. (1994). Estimation of the ED50 and its error by means of logarithmic-probit graph paper. Proc. Soc. Exptl. Biol. Med. 57, 261-264.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 650 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- > 587 - < 713
- Mortality:
- Motaliity was not affected.
- Clinical signs:
- other: A high incidence of diarrhea was noted with the use of the higher concentration. Those rats which succumbed appeared to be weak and showed reduced voluntary activity prior to death.
- Gross pathology:
- No significant gross abnormalities were seen at autopsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Acute oral LD50of LAS is 650 +/- 63 mg/kg (with a slope factor of 0.173) when the samples are administered in water dispersion to rats.
The acute oral LD50 in male/female rats is 650mg/kg bw. No significant gross abnormalities were seen at autopsy. - Executive summary:
An acute oral toxicity study was performed for linear alkylbenzene sulphonate (LAS: nominal chain lengh of 12 carbon atoms and an average molecular weight of 346) using rats (FDRL strain, 3/sex/dose) for 14 days. 10% and 40% dispersions of the LAS were prepared in distilled water and administered intragastrically. The animals were observed several times daily for behavior, appearance, and survival for a 14-day period. They were weighed initially and at 7 and 14 days. All animals that died on test as well as those sacrificed at the conclusion of the observation period were necropsied. The acute oral LD50 in rats is 650mg/kg bw.No significant gross abnormalities were seen at autopsy.
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