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Diss Factsheets
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EC number: 217-284-9 | CAS number: 1798-50-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referenced sources in an international report.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Hydrogen Chloride, SIDS Initial Assessment Report For SIAM 15
- Author:
- OECD
- Year:
- 2 002
- Bibliographic source:
- UNEP PUBLICATIONS
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- (1981)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hydrogen chloride
- EC Number:
- 231-595-7
- EC Name:
- Hydrogen chloride
- Cas Number:
- 7647-01-0
- IUPAC Name:
- chloride
- Reference substance name:
- Hydrochloric acid
- IUPAC Name:
- Hydrochloric acid
- Test material form:
- not specified
- Details on test material:
- 37% of hydrochloric acid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- - Test animals: Animals with healthy and intact skin were used.
- Test conditions: the dorsal and lateral parts of the trunk were shorn 15-24h before treatment. The results were assessed 1, 24, 48 and 72 hr and 7 days after removal of the patch.
Test system
- Type of coverage:
- other: occlusive and semi-occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- Amount: 0.5 mL of 37% HCl
Concentration: 12 mol/L - Duration of treatment / exposure:
- Both 1 and 4 hours exposure
- Observation period:
- 1, 24, 48 and 72 hr and 7 days after removal of the patch
- Number of animals:
- 6 animals per sex per dose
- Details on study design:
- Four samples were attached dorsally (laterally) to each animal. The local reactions were determined after both 1 and 4 hr exposure both under occlusive and semi-occlusive conditions. 0.5 mL/patch were applied to gauze pads 3 cm x 3 cm. The patches were fixed on the prepared skin areas of the flanks and covered by wrapping an airpermeable circular bandage (semi-occlusive method) or airtight plastic foil (occlusive method) around the animals. After removal of the bandages and patches the treated skin areas were rinsed with water and dried.
Results and discussion
In vivo
- Irritant / corrosive response data:
- The test substance was corrosive after both 1 hr and 4 hr application of occlusive or semi-occlusive exposure. However, the cumulative total and percent responders were not described.
Any other information on results incl. tables
Reference: Potokar, M. (1985) Studies on the Design of Animal Tests for the Corrosiveness of Industrial Chemicals. Fd. Chem. Toxic., 23, 615-617.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Classified as the material which causes buns according to EEC (1967)
- Conclusions:
- Hydrochloric acid at 37% is corrosive to skin. Azacyclonol base is considered to be non irritant to the skin. HCl is present in the mixture Azacyclonol HCl in a content of 11%. Azacyclonol HCl is expected to be at least slightly irritant for the skin.
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