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Diss Factsheets
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EC number: 233-881-7 | CAS number: 10411-92-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 1.2 µg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 12 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.12 µg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
- PNEC marine water (intermittent releases):
- 1.2 µg/L
STP
- Hazard assessment conclusion:
- no hazard identified
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.393 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.039 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.078 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 66.67 mg/kg food
- Assessment factor:
- 300
Additional information
Environmental fate and pathways
Based on the biodegradation studies (OECD Guideline 301 D), the registered substance is considered readily biodegradable. Two hydrolysis products were identified: acetate and 4 -tert-Butylcyclohexanol.Acetate can be considered as readily biodegradable too but insufficient data are available to assess the readily biodegradation of 4-tert-butylcyclohexanol. However, over 60% biodegradation were observed after 28 days. The parent and hydrolysis products are not persistent in the environment.The bioconcentration factor (BCF) of the registered substance was estimated using a QSAR predictions with a maximum value at 335 L/kg whole body weight, therefore the substance is not bioaccumulable according to CLP (BCF < 500) and PBT criteria (BCF < 2000). Finally, based on a read-across approach, the adsorption coefficient (log Koc) of the registered substance can be determined at 3.51 (OECD Guideline 121, EU Method C.19). This result indicates that the substance is environmentally slightly mobile (according to P.J. McCall et al., 1980).
Aquatic toxicity
One acute experimental study and four QSAR predictions are available to assess the aquatic toxicity of the registered substance.
The experimental study (Harlan, 2013), performed on the registered substance on aquatic invertebrates Daphnia magna, was not considered reliable due to major methodological deficiencies. Therefore, QSAR prediction for this endpoint, and all other endpoints required, were performed using iSafeRat® High-Accuracy-Quantitative Structure-Activity Relationship (KREATIS, 2020). Toxic effects below the solubility limit were predicted on algae and fish in acute conditions. For algae, the 72h-ErC50 value was predicted at 1.2 mg/L. For fish, the 96h-LC50 value was predicted at 2.6 mg/L. Finally, the toxicity values for daphnia in acute conditions (48h-EC50) and activated sludge (30-180min EC50) were predicted as greater than the limit of solubility within the exposure period of the tests.
Conclusion on classification
No harmonised classification is available for the registered substance.
The lowest E(L)C50 value of the registered substance for aquatic organisms is comprised between 1 and 10 mg/L (lowest value at 1.2 mg/L). However, as the substance is readily biodegradable, with predicted BCF values lower than 500, the registered substance is not classified for the environment according to the CLP Regulation (Annex I of the Regulation (EC) No 1272/2008 (CLP)).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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