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EC number: 246-025-2 | CAS number: 24124-40-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- October 28, 1988 - November 2, 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants)
- Principles of method if other than guideline:
- The purpose of the study was to estimate the eye irritancy potential of the test substance. Isolated bovine eyes (BE) were used to predict corneal damage whereas the chorioallantoic membrane (CAM) of chicken eggs indicated conjunctival irritancy.
The study was carried out as described in the following paper:
Waterings, P.J.J.M. and van Erp, Y.H.M. (1987). Alternative methods in Toxicology Vol. V: In Vitro Toxicology - Approaches to Validation. Ed. A.M. Goldberg, M.A. Liebert Inc. NY, USA. - GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-amino-4-(3-amino-2,4,6-trimethyl-5-sulphoanilino)-9,10-dihydro-9,10-dioxoanthracene-2-sulphonic acid
- EC Number:
- 246-025-2
- EC Name:
- 1-amino-4-(3-amino-2,4,6-trimethyl-5-sulphoanilino)-9,10-dihydro-9,10-dioxoanthracene-2-sulphonic acid
- Cas Number:
- 24124-40-1
- Molecular formula:
- C23H21N3O8S2
- IUPAC Name:
- 1-amino-4-[(3-amino-2,4,6-trimethyl-5-sulfophenyl)amino]-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- The following test substance data have been submitted by the sponsor, who accepts full responsibility for the validity thereof.
- Identity: FAT 92'185/A
- Batch No: EN 27.86
- Physical Appearance: solid
- Purity: AS: 55% humid/water
- Stability: unknown
- Storage: in the original container at room temperature in the dark
- Safety Precautions: lab coat and gloves will be sufficient to ensure personal health and safety
Test and reference substances
The investigated chemical substance was tested in the form it was provided by the sponsor. The reference substances toluene and acetone (p.a.) were purchased from Merck (Darmstadt, FRG). Purity and stability of the compounds were not confirmed.
Results and discussion
In vitro
Resultsopen allclose all
- Irritation parameter:
- other: mean interpretation score
- Run / experiment:
- BE assay
- Value:
- 1.5
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: slight irritating
- Irritation parameter:
- other: mean interpretation score
- Run / experiment:
- CAM assay
- Value:
- 0.38
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
Mean Cumulative Scores and Interpretation for FAT 92'185/A in the BECAM Assay
BE assay mean score interpretation |
CAM assay mean score interpretation |
final interpretation
|
1.5 slight |
0.38 non irritating |
slightly irritating |
For toluene, a score of 1.5 was obtained in the BE assay whereas the average score in the CAM assay was 1.0. Acetone treatment resulted in a score of 3.5 in the BE assay and an average score of 2.0 in the CAM assay. As the effects, produced by acetone and toluene, fell within the historical range and the untreated eyes and eggs showed no signs of irritation, the results were considered to be valid.
To evaluate the effects observed in both assays the documented in vivo effects of the two reference substances toluene and acetone were taken into consideration (3). Toluene produces slight transient conjunctival irritation with negligible to slight corneal epithelial damage without opacity in the rabbit eye, while no serious effects have been reported in case of accidental exposure of human eyes. Acetone causes temporary edema and moderate corneal opacity with epithelial damage to exposed rabbit eyes while in man reversible corneal opacity has been observed. The test substance revealed slight corneal damage consisting of slight opacification and affection of the epithelial integrity in all eyes. After extra rinsing the effects on the CAM were classified as negligible and consisted of vascular injection five minutes after application in egg no. 3 and minute bleedings after two minutes in egg no. 1,
Applicant's summary and conclusion
- Interpretation of results:
- other: slight irritation may be expected after acute eye exposure to FAT 92'185/A.
- Conclusions:
- It is concluded that slight irritation may be expected after acute eye exposure to FAT 92'185/A.
- Executive summary:
The substance revealed slight corneal damage and the effects on the CAM were classified as negligible. It is concluded that slight irritation may be expected after acute eye exposure to FAT 92185/A.
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