Registration Dossier
Registration Dossier
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EC number: 208-031-3 | CAS number: 506-30-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Skin irritation data for 57-11-4
- Year:
- 1 977
- Bibliographic source:
- Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill,V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977
- Reference Type:
- review article or handbook
- Title:
- RTECS NUMBER : WI2800000
- Author:
- RTECS Database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances);"Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill,V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977
Materials and methods
- Principles of method if other than guideline:
- Standard Draize test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Stearic acid
- EC Number:
- 200-313-4
- EC Name:
- Stearic acid
- Cas Number:
- 57-11-4
- Molecular formula:
- C18H36O2
- IUPAC Name:
- stearic acid
- Details on test material:
- - Name of test material (as cited in study report):Stearic acid
- Molecular formula:C18H36O2
- Substance type:Organic
Constituent 1
Test animals
- Species:
- human
Test system
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 75 mg
- Duration of treatment / exposure:
- 3D (Intermittent)
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 3 Days
- Reversibility:
- no data
- Remarks on result:
- other: Mild irritant
Applicant's summary and conclusion
- Interpretation of results:
- other: mild irritant
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Skin irritation tests performed by the method of Standard Draize test,75 mg of Stearic acid applied to the skin of human subjects for 3 days where the dosage of stearic acid was given intermittently, resulted in a mild irritation effect." The substance Stearic acid is thus considered "mildly irritating."
- Executive summary:
Skin irritation tests performed by the method of Standard Draize test,75 mg of Stearic acid applied to the skin of human subjects for 3 days where the dosage of stearic acid was given intermittently, resulted in a mild irritation effect." The substance Stearic acid is thus considered "mildly irritating."
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