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EC number: 603-087-9 | CAS number: 125700-67-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation
- Adequacy of study:
- supporting study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: reexposition test of a male human
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
- Principles of method if other than guideline:
- Nasal chellenge test with 1 mg/ml, Peak nasal inspiratory flow was measured.
- GLP compliance:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- TBTU in the study is reported as 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate with the structural formula for this substance, which is not equal to the substance identity of CAS: 125700-67-6 (with the correct CAS name 1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, 3-oxide, tetrafluoroborate(1-)) of this registration.
no further details cited
Constituent 1
Test animals
- Species:
- human
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Six years of occupational exposure (since 1996), symptoms after 3 years of occupational exposure.
Test system
- Route of induction exposure:
- inhalation
- Route of challenge exposure:
- intranasal
- Vehicle:
- other:
- Concentration:
- 1 mg/ml
- No. of animals per dose:
- 10 control persons
- Details on study design:
- It is not quite clear whether PBS was used as vehicle for the nasal challenge test. The sensitized person was exposed to 1 mg TBTU/ml in the nasal challenge test.
Peak nasal inspiratory flow was measured. - Challenge controls:
- 10 persons served as control group
Results and discussion
- Results:
- A sensitized person was exposed to 1 mg TBTU/ml in a nasal chellenge test with 1 mg/ml.
Peak nasal inspiratory flow (PNIF) was measured. Reduction of 60% occured.
10 control persons had with the same challenge no reduction of PNIF. - Negative control results:
- 10 other persons
Applicant's summary and conclusion
- Interpretation of results:
- ambiguous
- Executive summary:
A single case of occupational contact uticaria, rhinoconjunctivitis, wheezing and dyspnea was observed after three years of occupational exposure to TBTU.
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