Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 200-795-6 | CAS number: 73-22-3
Endpoint summary
Administrative data
Description of key information
Additional information
According to REACH Regulation (Annex VIII, 9.2.2.1, column 2), the study on hydrolysis does not need to be done if the test substance is readily biodegradable. In a GLP guideline study, L-tryptophan proved to be readily biodegradable and fulfilling the 10-d-window criterion (77% biodegradation after 28 d). According to REACH Regulation (Annex IX, 9.2.1.2, 9.2.1.3, and 9.2.1.4, column 2), the studies on biodegradation in water, sediment (simulation tests) and in soil do not need to be done if the test substance is readily biodegradable. L-Tryptophan proved to be readily biodegradable. According to REACH Regulation (Annex IX, 9.2.1.2, column 2), the study on bioaccumulation does not need to be done if a low potential for bioaccumulation is to be expected (e.g. log Pow < 3). The study on bioaccumulation does not need to be performed based on the experimentally determined log Pow of -1.06 which indicates a very low bioaccumulation. According to REACH Regulation (Annex VIII, 9.3.1, column 2), the study on adsorption/desorption does not need to be done if based on physico-chemical properties (e.g. low n-octanol/water partition coefficient log Pow) a low soil sorption is to be expected or based on the biodegradation the substance itself and his relevant degradation products break down quickly. L-Tryptophan has a log Pow=-1.06 and proved to be readily biodegradable. Testing is therefore not necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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