Registration Dossier
Registration Dossier
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EC number: 618-883-1 | CAS number: 92878-95-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 15- 31 July 2009
- Reliability:
- 1 (reliable without restriction)
Data source
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese Ministry of Agriculture, Forestry and Fisheries (JMAFF), 12 Nousan, Notification No 8147, November 2000, including the most recent partial revisions..
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 2-(3-chloropropoxy)-1-methoxy-4-nitrobenzene
- EC Number:
- 618-883-1
- Cas Number:
- 92878-95-0
- Molecular formula:
- C10H12ClNO4
- IUPAC Name:
- 2-(3-chloropropoxy)-1-methoxy-4-nitrobenzene
- Details on test material:
- Molecular formula C10H12ClNO4
Molecular weight 245.66
CAS Number 92878-95-0
Description Slightly yellow powder
Batch 18238702
Purity 99.8%
Test substance storage At room temperature protected from light
Stability under storage conditions Stable
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Remarks:
- Merck, Darmstadt, Germany (specific gravity 1.036)
- Doses:
- 2000 mg/kg (10 mL/kg) body weight.
Frequency Single dosage, on Day 1. - No. of animals per sex per dose:
- 6 Females (nulliparous and non-pregnant). Each dose group consisted of 3 animals.
Young adult animals (approx. 8 weeks old) were selected. Body weight variation did not exceed +/- 20% of the sex mean - Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
Any other information on results incl. tables
The oral LD50 value of WAY-188471 in Wistar rats was established to exceed 2000 mg/kg body weight.
According to the OECD 423 test guideline, the LD50 cut-off value was considered to exceed 5000 mg/kg body weight.
Based on these results, WAY-188471 does not have to be classified and has no obligatory labeling requirement for acute oral toxicity according to the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) of the United Nations (2007) and the Regulation (EC) No 1272/2008 on classification, labeling and packaging of substances and mixtures.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- Based on these results, WAY-188471 does not have to be classified and has no obligatory
labeling requirement for acute oral toxicity according to the Globally Harmonized System of
Classification and Labeling of Chemicals (GHS) of the United Nations (2007) and the Regulation
(EC) No 1272/2008 on classification, labeling and packaging of substances and mixtures.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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