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Diss Factsheets
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EC number: 931-210-9 | CAS number: 1266534-73-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles; however, the test was not performed until reversibility of effects (conjunctival redness).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Department of Transportation, Code of Federal Regulations, Title 49, part 173
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 930-915-9
- EC Number:
- 930-915-9
- IUPAC Name:
- 930-915-9
- Details on test material:
- - Name of test material (as cited in study report): Code 504 Can #19a
- Related CAS number: 1318-02-1
- Physical state: white fine powder
- Analytical purity: no data
- surface modified with approx. 10% rare earth elements
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand Albino
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 100 mg (powder), undiluted
not rinsed - Duration of treatment / exposure:
- 72 h
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Following a 7 day acclimation, the rabbits (New Zealand Albinos) were screened for ocular irritation by pen light examination. This was followed by fluorescein staining and observation of the cornea using an ultra-violet lamp. A 100 mg (powder) sample was instilled into the conjunctival sac of one eye of each of 6 rabbits. The opposite eye remained untreated and served as the control. The eyes were examined at 24, 48 and 72 hours and graded for irritation according to the "Illustrated Guide for Grading Eye Irritation by Hazardous Substances".
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- animal 1-6
- Time point:
- other: 24-72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- animal 1-6
- Time point:
- other: 24-72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24-72 h
- Score:
- 1
- Reversibility:
- not fully reversible within: 3 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24-72 h
- Score:
- 0.3
- Reversibility:
- fully reversible within: 3 d
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- animal 3-6
- Time point:
- other: 24-72 h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- animal 1-6
- Time point:
- other: 24-72 h
- Score:
- 0
- Irritant / corrosive response data:
- No findings were recorded concerning cornea and iris. Conjunctivae of 2/6 animals revealed slight redness at observation day one. This slight redness was lasting in one animal until observation day 3. Chemosis of the conjunctivae was not observed in all 6 test animals.
The test substance would not be considered an ocular irritant under the conditions of this test.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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