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Diss Factsheets
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EC number: 401-620-8 | CAS number: 87731-18-8 VIOLIFF
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The substance has a half-life at 25°C of >1 year at pH 4 and pH 7, and 30 days at pH 9.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Hydrolysis of the substance as a function of pH was examined in a study according to OECD TG 111 and in compliance with GLP (Huntingdon, 2005). Sample solutions were prepared in Wheaton vials by adding defined nominal concentrations to sterile buffer solutions with pH4, 7, and 9 and maintained at 50°C for a period of up to 120 hours. The solutions were shielded from light. In the preliminary test, <10% hydrolysis was observed (based on summed peak area) at pH 4 and pH 7 after 5 days at 50°C, and therefore further testing was not required. The half-life time of the test substance at these pH values is concluded to be >1 year under environmental conditions (25°C). It should be noted however, that at these pH values the degree of hydrolysis may be underestimated due to data evaluation based on summed peak areas. From the reported data it cannot be determined if these summed peak areas contain a contribution from degradation products, or if these chromatographs are outside the retention window of the test substance. Furthermore, information on vial headspace and type of vial closure (caps) has not been reported, and although some extent of volatilisation, especially at elevated temperatures, cannot be excluded.
In the preliminary test 82% was observed at pH 9, also based on summation of peak areas in the retention time range 16-21 minutes. Consequentially, higher tier tests were performed at this pH and the half-life at 25°C determined to be ca. 30 days. Ideally, the decrease of individual peaks and arising of new peaks in the indicated retention time range should have been monitored throughout the tests to exclude the possibility of contribution from degradation products to the summed peak area. However, as such monitoring was not performed in this test, it is not possible to conclude if quantification of test substance concentrations in the samples was performed correctly. As a direct consequence the derived log Ct values may not be correct, leading to potentially different regressions curves (slopes), which in turn were used to derive hydrolysis rate constants and environmental half-life times. Therefore the reported half-life time of approximately 30 days at pH 9 has some uncertainties and should be treated with care. Altogether, based on the previous, the environmental half-life at 25 °C is determined to be >1 year for the substance.
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