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EC number: 284-716-0 | CAS number: 84962-20-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7. Apr – 28. Apr 1976
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- performed before GLP guidelines
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Knapsack-Reinigerkomponente GB LP Kn 164
- IUPAC Name:
- Knapsack-Reinigerkomponente GB LP Kn 164
- Test material form:
- liquid: viscous
- Details on test material:
- colorless viscous liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG Kastengrund - SPF breed
- Weight at study initiation 88-111 g:
- Fasting period before study: 16 h
- Housing: in Macrolon cages with softwood bedding
- Diet (e.g. ad libitum): Altromin 1324 (Altromin GmbH, Lage/Lippe), ad libitum
- Water (e.g. ad libitum): Tap water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- concentration in vehicle: 10 %
- Doses:
- 1600, 2500, 3200, 4000 or 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 females/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations daily after application / Weighing once weekly
- Necropsy of survivors performed: yes - Statistics:
- Probit analysis (method by Linder and Weber);
Confidence limits according to Cavalli-Sforza
Results and discussion
- Preliminary study:
- Preliminary experiments did not show differences related to gender. Therefore only females used for main study.
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 575 mg/kg bw
- 95% CL:
- > 3 306 - <= 3 865
- Mortality:
- Dose: 1600 mg/kg bw, Mortality rate: 0 / 10
Dose: 2500 mg/kg bw, Mortality rate: 0 / 10
Dose: 3200 mg/kg bw, Mortality rate: 2 / 10
Dose: 4000 mg/kg bw, Mortality rate: 8 / 10
Dose: 5000 mg/kg bw, Mortality rate: 10 / 10 - Clinical signs:
- other: closed eye lid, abnormal breathing, crouched posture Mortally poisened animals died within 1-2 days after application.
- Gross pathology:
- Dissection of rats killed at the end of the observation period revealed no macroscopic findings.
Necropsy of the deceased animals revealed following macroscopic findings: Stomach mucosa reddened, stomach filled with bloody content
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The median lethal dose of the test item was 3575 mg per kg body weight. Based on the result of this study the test substance is not subject for labelling and classification according to regulatory requirements.
- Executive summary:
The test item was tested for its acute oral toxicity potential. 10 female rats were treated with doses of 1600, 2500, 3200, 4000 or 5000 mg/kg bw and observed for 14 days.
The median lethal dose of test item (LD50) was 3575 mg per kg body weight. Based on the result of this study the test substance is not subject for labelling and classification according to regulatory requirements.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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