3,6,7-trimethyloct-6-en-1-yn-3-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well performed and adequately described study with a complete test report, the only shortcoming is that the purity of the test substance was not specified.

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Report date:

1997

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test type:

fixed dose procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,6,7-trimethyloct-6-en-1-yn-3-ol

EC Number:

258-011-3

EC Name:

3,6,7-trimethyloct-6-en-1-yn-3-ol

Cas Number:

52567-96-1

Molecular formula:

C11H18O

IUPAC Name:

3,6,7-trimethyloct-6-en-1-yn-3-ol

Test animals

Species:

rat

Strain:

other: Crl: CD (SD) BR strain (VAF plus)

Sex:

male/female

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

unchanged (no vehicle)

Doses:

500 and 2000 mg/kg bw

No. of animals per sex per dose:

5 male, 5 female

Control animals:

no

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

male/female

Dose descriptor:

LD0

Effect level:

>= 500 mg/kg bw

Based on:

test mat.

Any other information on results incl. tables

-

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The results of this study indicate that the maximum tolerated oral dose (LD0) of Methyl
Dehydrolinalool lies between 500 and 2000mg/kg bodyweight.

Executive summary:

Since the results of the range finding study, using female rats, indicated that a dose level of 2000mg/kg produced no mortality, in the main study the test article was administered at this dose level as a single oral dose to a group of 5 male and 5 female rats which had been fasted overnight. The animals were examined frequently on the day of dosing and daily thereafter for a further 14 days at the end of which, the survivors were killed and subjected to necropsy. As 2 males in this first group were killed due to the severity of clinical signs, test article at a dose level of 500mg/kg was administered to a second group of 5 males and 5 females. These animals were examined daily for 15 days and were then killed and subjected to necropsy. Treatment with the test article at a dose level of 2000mg/kg produced hypoactivity in all the males and one female on the day of dosing. Most of these animals were also incoordinate. In 2 males reaction to treatment became progressively more severe and as a consequence, these animals were killed 6 hours after dosing. All the remaining males and the affected female appeared to have recovered by day 2. Treatment with the test article at a dose level of 500mg/kg produced no mortalities or significant clinical signs of toxicity. There was no adverse effect on bodyweight gain in any animal of either sex dosed with test article at 500 or 2000mg/kg. At necropsy, no significant abnormalities were detected in any animal of either sex dosed with test article at 500 or 2000mg/kg.