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EC number: 203-910-8 | CAS number: 111-81-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Two in vitro studies were performed on Methyl-10-undecenoate in the years 1995 and 2002, respectively. Both the bacterial reverse mutation rate test (Ames Test) and a mammalian chromosomal aberration test revealed negative results. Concerning the mammalian cell gene mutation tests a read across with undecylenic acid is being proposed (also negative study outcome). No in-vivo studies needed to be carried out yet for methyl 10-undecenoate.
The Ames test was achieved on Salmonella typhimurium strains: TA 1535, TA 1537, TA 98, TA 100 and TA 102, with and without metabolic activation. Test item concentrations up to 5000 µg/plate were tested. Methyl undecylenate did not reveal any mutagenic activity, despite its toxicity to bacteria.
This lack of mutagenic properties was confirmed by a chromosomal aberrations test carried out on human lymphocytes. Those cells were exposed with and without metabolic activation at the following doses : 1.25, 2.5, 5 and 10 mM. No significant chromosomal aberrations were noticed. In-vivo studies were not required for this substance.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
As indicated above, the available in vitro studies on genetic toxicity gave negative results, thus no classification of methyl 10 -undecenoate is warranted for genotoxicity according to EU regulation (EC) No. 1272/2008 (CLP) and to EU 67/548/ECC classification system.
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