[(1E)-7-methyl-5-oxo-1-phenyloct-1-en-3-yl]malonic acid

Guidance on Safe Use

First-aid measures

SECTION 4: First aid measures

IF exposed or concerned: Get medical advice/attention. Ensure that medical personnel are aware

of the material(s) involved, and take precautions to protect themselves.

General information

4.1. Description of first aid measures

If exposed to excessive levels of dusts or fumes, remove to fresh air and get medical attention if

cough or other symptoms develop. Move to fresh air. If breathing is difficult, trained personnel

should give oxygen.

Inhalation

Immediately flush skin with plenty of water. Take off contaminated clothing and wash before reuse.

Get medical attention if symptoms occur.

Skin contact

Eye contact

If swallowed, rinse mouth with water (only if the person is conscious). Call a physician or poison

control centre immediately. Only induce vomiting at the instruction of medical personnel. Never

give anything by mouth to an unconsious person. Do not induce vomiting without advice from

poison control center.

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

Ingestion

4.2. Most important symptoms

and effects, both acute and

delayed

Dusts may irritate the respiratory tract, skin and eyes.

4.3. Indication of any

immediate medical attention

and special treatment needed

No specific antidotes are recommended. Treat according to locally accepted protocols. For

additional guidance, refer to the current prescribing information or to the local poison control

information centre.

Fire-fighting measures

SECTION 5: Firefighting measures

General fire hazards

5.1. Extinguishing media

Water. Foam. Dry chemical powder.

May form combustible dust concentrations in air. This material will support combustion.

Suitable extinguishing

media

Unsuitable extinguishing

media

Carbon dioxide (CO2).

5.2. Special hazards arising

from the substance or mixture

Explosion hazard: Avoid generating dust; fine dust dispersed in air in sufficient concentrations and

in the presence of an ignition source is a potential dust explosion hazard. During fire, gases

hazardous to health may be formed.

5.3. Advice for firefighters

Self-contained breathing apparatus and full protective clothing must be worn in case of fire.

Special protective

equipment for firefighters

In case of fire and/or explosion do not breathe fumes. Move containers from fire area if you can do

so without risk. Apply extinguishing media carefully to avoid creating airborne dust.

Special fire fighting

procedures: In case of fire and/or explosion do not breathe fumes. Move containers from fire area if you can do

so without risk. Apply extinguishing media carefully to avoid creating airborne dust.

Specific methods: Use standard firefighting procedures and consider the hazards of other involved materials.

Accidental release measures

Specific methods

Use standard firefighting procedures and consider the hazards of other involved materials.

SECTION 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures

Keep unnecessary personnel away. Keep people away from and upwind of spill/leak. Use only

non-sparking tools. Dust deposits should not be allowed to accumulate on surfaces, as these may

form an explosive mixture if they are released into the atmosphere in sufficient concentration.

Wear appropriate protective equipment and clothing during clean-up. Ensure adequate ventilation.

Local authorities should be advised if significant spillages cannot be contained. For personal

protection, see section 8 of the SDS.

For non-emergency

personnel

Keep unnecessary personnel away. Use personal protection recommended in Section 8 of the

SDS.

For emergency responders

6.2. Environmental precautions

Eliminate all ignition sources (no smoking, flares, sparks, or flames in immediate area). Take

precautionary measures against static discharge. Use only non-sparking tools. Avoid dispersal of

dust in the air (i.e., clearing dust surfaces with compressed air). Collect dust using a vacuum

cleaner equipped with HEPA filter. Stop the flow of material, if this is without risk.

Avoid discharge into drains, water courses or onto the ground.

6.3. Methods and material for

containment and cleaning up

Large Spills: Wet down with water and dike for later disposal. Shovel the material into waste

container. Following product recovery, flush area with water.

Small Spills: Sweep up or vacuum up spillage and collect in suitable container for disposal.

Never return spills to original containers for re-use.

Handling and storage

7.1. Precautions for safe

handling

Minimise dust generation and accumulation. Avoid significant deposits of material, especially on

horizontal surfaces, which may become airborne and form combustible dust clouds and may

contribute to secondary explosions. Routine housekeeping should be instituted to ensure that

dusts do not accumulate on surfaces. Dry powders can build static electricity charges when

subjected to the friction of transfer and mixing operations.  Provide adequate precautions, such as

electrical grounding and bonding, or inert atmospheres. Keep away from heat/sparks/open

flames/hot surfaces. - No smoking. Explosion-proof general and local exhaust ventilation. Avoid

prolonged exposure. Wear appropriate personal protective equipment. Observe good industrial

hygiene practices. Minimise the use of plastics when handling this material.

Keep away from heat, sparks and open flame. Keep containers tightly closed in a dry, cool and

well-ventilated place. Store away from incompatible materials (see Section 10 of the SDS).

7.2. Conditions for safe

storage, including any

incompatibilities

7.3. Specific end use(s)

Isolated Chemical Intermediate.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

PROVISIONAL

Biological limit values

No biological exposure limits noted for the ingredient(s).

Recommended monitoring

procedures

Follow standard monitoring procedures.

Derived no effect levels

(DNELs)

Not available.

Predicted no effect

concentrations (PNECs)

Not available.

8.2. Exposure controls

Ventilate as needed to control airborne dust. Use explosion-proof ventilation equipment if airborne

dust levels are high. Use process enclosures, local exhaust ventilation, or other engineering

controls to control airborne levels below recommended exposure limits. If engineering measures

are not sufficient to maintain concentrations of dust particulates below the OEL (occupational

exposure limit), suitable respiratory protection must be worn.

Appropriate engineering

controls

Individual protection measures, such as personal protective equipment

Use personal protective equipment as required. Personal protection equipment should be chosen

according to the CEN standards and in discussion with the supplier of the personal protective

equipment. Follow all local regulations if personal protective equipment (PPE) is used in the

workplace.

General information

Eye/face protection

Wear safety glasses with side shields (or goggles). (e.g. EN 166). Eye wash fountain is

recommended.

Skin protection

Wear appropriate chemical resistant gloves. Select suitable chemical resistant protective gloves

(EN 374) with a protective index 6 (>480min permeation time). The choice of an appropriate glove

does not only depend on its material but also on other quality features and is different from one

producer to the other.

- Hand protection

- Other

If engineering controls do not maintain airborne concentrations below recommended exposure

limits (where applicable) or to an acceptable level (in countries where exposure limits have not

been established), an approved respirator must be worn. Where breathable aerosols/dust are

formed, use suitable combination filter for gases/vapours of organic, inorganic, acid inorganic,

alkaline compounds and toxic particles (eg. EN 14387).

Wear appropriate chemical resistant clothing. (EN 14605 for splashes, EN ISO 13982 for dust).

Respiratory protection

Thermal hazards

Always observe good personal hygiene measures, such as washing after handling the material

and before eating, drinking, and/or smoking.  Routinely wash work clothing and protective

equipment to remove contaminants.

Wear appropriate thermal protective clothing, when necessary.

Hygiene measures

Environmental exposure controls

Hazard guidance and

control recommendations

Contain spills and prevent releases and observe national regulations on emissions. Ensure

discharge to the aquatic environment does not exceed the EHAC for this material. Environmental

manager must be informed of all major releases.

Stability and reactivity

SECTION 10: Stability and reactivity

10.1. Reactivity

Material is stable under normal conditions.

The product is stable and non-reactive under normal conditions of use, storage and transport.

10.2. Chemical stability

No dangerous reaction known under conditions of normal use.

10.3. Possibility of hazardous

reactions

Keep away from heat, sparks and open flame. Contact with incompatible materials. Minimise dust

generation and accumulation. Avoid dispersion as a dust cloud.

10.4. Conditions to avoid

10.5. Incompatible materials

Irritating and/or toxic fumes and gases may be emitted upon the product's decomposition.

Not available.

10.6. Hazardous

decomposition products

Disposal considerations

13.1. Waste treatment methods

Dispose of in accordance with local regulations. Empty containers or liners may retain some

product residues. This material and its container must be disposed of in a safe manner (see:

Disposal instructions).

Residual waste

Contaminated packaging

Since emptied containers may retain product residue, follow label warnings even after container is

emptied. Empty containers should be taken to an approved waste handling site for recycling or

disposal.

EU waste code

The Waste code should be assigned in discussion between the user, the producer and the waste

disposal company.

Collect and reclaim or dispose in sealed containers at licensed waste disposal site. Dispose in

accordance with all applicable regulations.

Disposal methods/information

Special precautions

Dispose in accordance with all applicable regulations.