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Diss Factsheets
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EC number: 700-334-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Toxicokinetic Behaviour:
The substance is a colourless liquid and has a relatively high molecular weight.
The low vapour pressure (1.8 x 10-5 Pa at 25ºC), high flash point and predicted negative explosive and oxidising properties shows that the substance is non-volatile and therefore inhalation is not a significant route of exposure.
The substance has a high log octanol/water partition coefficient (Log Pow >6.5) and low water solubility (0.224 mg/l).
The substance is considered to be a skin sensitiser but is not a skin irritant.
A repeated dose reproductive screening study, on a structural analogue substance, showed limited evidence of absorption and did not show evidence of metabolism or excretion.
The substance was non-mutagenic in bacteria in either the absence or presence of an auxiliary metabolising system. A structural analogue substance was non-clastogenic in mammalian cells in vitro (human lymphocytes) and non-mutagenic in mammalian cells in vitro (L5178Y mouse lymphoma cell line) in either the absence or presence of an auxiliary metabolising system.
Absorption:
The results of an acute oral toxicity study in rats and repeated dose oral toxicity study in rats showed no evidence of significant absorption of the substance.
The molecular weight, high log Pow and low water solubility of the substance indicate absorption would be limited from the gastrointestinal tract following oral ingestion. Any absorption that occurs for this lipohilic substance may be by micellular solubilisation.
The results of an acute dermal toxicity in rats showed no evidence of significant absorption of the substance and no systemic toxicity was observed in skin irritation and skin sensitisation studies. Absorption via the skin is expected to be low due to the molecular weight, log Pow and low water solubility of the substance.
The substance is a skin sensitiser based on LLNA study, so some uptake will have occurred although it may only have been a small fraction of the applied dose. The substance is not a skin irritant so significant damage to the skin surface should not occur to enhance penetration.
Distribution:
There is no significant evidence to suggest widespread distribution of the substance will occur. This is supported by the low water solubility of the substance.
The positive response in a skin sensitization study suggests that the substance may bind to carrier proteins in the circulatory systems, thereby facilitating potential systemic distribution.
The high partition coefficient result (log Pow >6.5) would suggest an affinity to accumulate in fatty tissues.
Metabolism:
The results of the repeated dose/reproduction screening study (conducted on a structural analogue substance) did not show evidence to indicate any substance influenced hepatic metabolism.
The results of the genotoxicity assays have shown that genotoxicity is neither enhanced or diminished in the presence of a metabolising system.
Excretion:
There is no evidence to indicate the route of excretion but poorly water-soluble products are not favourable for urinary excretion and therefore biliary excretion may well be a significant route for this material. Any substance that is not absorbed will be excreted in the faeces.
Key value for chemical safety assessment
- Bioaccumulation potential:
- high bioaccumulation potential
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.