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EC number: 416-530-4 | CAS number: 178949-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-06-21 to 1993-06-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- static method
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 1.9 Pa
- Conclusions:
- In a GLP study conducted according to OECD Guideline 104, the vapour pressure of trisodium EDDS at 25°C was calculated to be 1.9 Pa
- Executive summary:
In a GLP study conducted according to OECD Guideline 104, the vapour pressure of trisodium EDDS was measured using the static method at three temperatures (36.25, 30.08 and 24.55oC) and the value at 25oC (calculated by fitting the data using the method of Clark and Grew) was 1.9 Pa.
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1996-10-29 to 1996-10-31
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of method:
- static method
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0.38 Pa
- Conclusions:
- In a GLP study conducted according to OECD Guideline 104, the vapour pressure of trisodium EDDS at 20°C was determined to be 0.38 Pa
- Executive summary:
In a GLP study conducted according to OECD Guideline 104, the vapour pressure of trisodium EDDS was measured using the static method at three temperatures (37, 29.96 and 24.31oC) and the value at 20oC (calculated by fitting the data using the method of Clark and Grew) was 0.38 Pa.
- Endpoint:
- vapour pressure
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 13 to 29 May 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: vapour pressure balance
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- < 0 Pa
- Conclusions:
- In a GLP study conducted according to EU Method A.4, the vapour pressure of EDDS acid at 25°C was calculated to be less than 1.7 x 10-4 Pa.
- Executive summary:
In a GLP study conducted according to EU Method A.4, the vapour pressure of EDDS acid was assessed using the vapour pressure balance system, with measurements made at several temperatures and from imposing a regression slope. The value at 25oC was calculated as less than 1.7 x 10 -4 Pa.
[Data on EDDS free acid is considered relevant to use for understanding the potential vapour pressure of trisodium EDDS, and is acceptable for using as read-across.]
Referenceopen allclose all
A total of 97 measurements were made. Mean of selected measurements at 36.25oC (#30 to 44), 30.08oC (#55 to 66) and 24.55oC (#80 to 97) fitted by method of Clark & Grew to give value at 25oC.
Mean of selected measurements at 37oC (#30 to 69), 29.96oC (#77 to 87) and 24.31oC (#100 to 117) was 5.16, 1.88 and 0.75 Pa, respectively
A total of 5 runs were carried out, each consisting of 11 data entires. The temperature range is between 120°C to 130°C. No statistical analysis is given for any run, due to the nature of the plot. It was considered more appropriate to impose a regression slope on a chosen data point (129°C of run 5) as an estimate of the maximum value for the vapour pressure at 25°C.
Description of key information
In two GLP studies conducted according to OECD Guideline 104 (using the static method), the vapour pressure of trisodium EDDS was determined .to be 0.38 Pa at 20°C (Krips and van Genderen, 1996) and 1.9 Pa at 25°C (de Vries and van Genderen, 1993).
However, a very low vapour pressure (of 6.53 x 10-15 Pa) was calculated (based on chemical structure) for trisodium EDDS using Syracuse software. 7
In addition, in a GLP study conducted according to EU Method A.4, the vapour pressure of EDDS acid was assessed using the vapour pressure balance system, with measurements made at several temperatures and from imposing a regression slope. The value at 25°C was calculated as less than 1.7 x 10 -4 Pa (Tremain, 2002).
[Data on EDDS acid is considered relevant to use for understanding the potential vapour pressure of trisodium EDDS, and is acceptable for using as read-across information.]
Key value for chemical safety assessment
- Vapour pressure:
- 0.002 kPa
- at the temperature of:
- 25 °C
Additional information
In two GLP studies (conducted according to OECD Guideline 104) using the static method, the vapour pressure of trisodium EDDS was determined to be 0.38 Pa at 20°C (Krips and van Genderen, 1996) and 1.9 Pa at 25°C (de Vries and van Genderen, 1993). However, in comparison with other related sodium salts, these values appear to be abnormally high. [In view of the nature of the substance, the vapour pressure is probably due to volatile impurities with the substance having a much lower value.]
Therefore, the vapour pressure of trisodium EDDS was calculated using the Syracuse Software, Module MPBP v.1.10. This software packages estimates vapour pressure based on chemical structure. The estimated value for trisodium EDDS was 4.97 x 10-17 mm Hg, or 6.53 x 10-15 Pa. Very low vapour pressures are expected for other simple salts of the EDDS moiety.
The reason for the marked difference between the experimental results and that of the computer model is likely to be associated with the hygroscopic nature of trisodium EDDS, the high measured values being attributed to water vapour generated from adsorbed water not completely removed during the sample preparation steps.
In addition, in a GLP study conducted according to EU Method A.4, the vapour pressure of EDDS acid was assessed using the vapour pressure balance system, with measurements made at several temperatures and from imposing a regression slope. The value at 25oC was calculated as less than 1.7 x 10 -4 Pa. [Data on EDDS free acid is considered relevant to use for understanding the potential vapour pressure of trisodium EDDS, and is acceptable for using as read-across information.]
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