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EC number: 289-070-3 | CAS number: 85959-75-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the skin sensitization potential of the test chemical Hydrogen bis[3-[[1-(3-chlorophenyl)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-4-yl]azo]-4-hydroxy-N-methylbenzenesulphonamidato(2-)] cobaltate(1-) (CAS No: 85959-75-7). The studies are as mentioned below:
The skin sensitization potential of test chemical was evaluated by authoritative database using Guinea pig maximization test. The test material in induction treatment was subjected onto the skin of guinea pig by intra-cutaneous injections of 0.1 ml of 0.1 % aqueous solution three times per day for 5 successive days followed by one intracutaneous challenge injection of the same solution after 4 weeks of induction treatment. No skin allergic reactions were observed. Hence, the test material was considered to be not skin sensitizing.
The above result was further supported by another skin sensitization study reported by same authoritative database for another read across chemical. In this study, the skin sensitization potential of test chemical was assessed in a 16 year period study. During the entire study, the cosmetic use of test chemical did cause a single case of contact allergy in humans within the 16 year period. Hence the test chemical was considered to be not sensitizing to the human skin.
Based on the above summarized studies for target chemical Hydrogen bis[3-[[1-(3-chlorophenyl)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-4-yl]azo]-4-hydroxy-N-methylbenzenesulphonamidato(2-)] cobaltate(1-) (CAS No: 85959-75-7) and its structurally and functionally similar read across substances,it can be concluded that the testchemical is unable to cause skin sensitization and considered as non-skin sensitizer. Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally and functionally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on 2 skin sensitization studies as- WoE-2 and WoE-3.
Skin sensitization test was conducted on guinea pigs and humans to determine the potential of skin sensitization caused by the chemical. - GLP compliance:
- not specified
- Type of study:
- other: 1.guinea pig maximisation test 2.Not specified
- Justification for non-LLNA method:
- not specified
- Specific details on test material used for the study:
- Name: Hydrogen bis[3-[[1-(3-chlorophenyl)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-4-yl]azo]-4-hydroxy-N-methylbenzenesulphonamidato(2-)] cobaltate(1-)
Molecular Formula: C34H28Cl2CoN10O8-S2.H
Molecular Weight: 899.6361 g/mole
InChI:1S/C17H16ClN5O4S.C17H15ClN5O4S.Co/c2*1-10-16(17(25)23(22-10)12-5-3-4-11(18)8-12)21-20-14-9-13(6-7-15(14)24)28(26,27)19-2;/h3-9,19,24-25H,1-2H3;3-9,16H,1-2H3,(H,21,24);/q;-1;+3/p-2/b21-20+;; - Species:
- other: 1.guinea pig 2.human
- Strain:
- other: 1. Not specified 2.Not applicable
- Details on test animals and environmental conditions:
- No data available
- Route:
- intradermal
- Vehicle:
- water
- Concentration / amount:
- 0.1 ml of 0.1 % aqueous solution
- Day(s)/duration:
- 5 days
- Adequacy of induction:
- other: WoE-2
- Route:
- other: No data available
- Adequacy of induction:
- other: WoE-3
- No.:
- #1
- Route:
- intradermal
- Vehicle:
- water
- Concentration / amount:
- 0.1 ml of 0.1 % aqueous solution
- Day(s)/duration:
- Not specified
- Adequacy of challenge:
- other: WoE-2
- Route:
- other: No data available
- Adequacy of challenge:
- other: WoE-3
- No. of animals per dose:
- Not specified
- Details on study design:
- 1. A. INDUCTION EXPOSURE
- No. of exposures: 3 times/ day for 5 successive days
- Exposure period: not speccified
- Test groups: not specified
- Control group: not specified
- Site: not specified
- Frequency of applications: 3 times a day
- Duration: not specified
- Concentrations: 0.1 ml of 0.1 % aqueous solution
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: not specified
- Exposure period: not specified
- Test groups: not specified
- Control group: not specified
- Site: not specified
- Concentrations: 0.1 ml of 0.1 % aqueous solution
- Evaluation (hr after challenge): not specified
OTHER: challenge treatment was provided 4 weeks after the induction
2.Not specified - Challenge controls:
- not specified
- Positive control substance(s):
- not specified
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 0.1 ml of 0.1 % aqueous solution
- Clinical observations:
- No skin allergic reactions were observed.
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- No data available
- No. with + reactions:
- 0
- Clinical observations:
- A 16-years period of use in cosmetics not a single case of allergy in humans.
- Remarks on result:
- no indication of skin sensitisation
- Cellular proliferation data / Observations:
- 1.No skin allergic reactions were observed.
2.A 16-years period of use in cosmetics not a single case of allergy in humans. - Interpretation of results:
- other: Not sensitizing
- Conclusions:
- The test material Hydrogen bis[3-[[1-(3-chlorophenyl)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-4-yl]azo]-4-hydroxy-N-methylbenzenesulphonamidato(2-)] cobaltate(1-) (CAS No: 85959-75-7) was considered to be not sensitizing to the skin of guinea pigs and humans.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the skin sensitization potential of the test chemical Hydrogen bis[3-[[1-(3-chlorophenyl)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-4-yl]azo]-4-hydroxy-N-methylbenzenesulphonamidato(2-)] cobaltate(1-) (CAS No: 85959-75-7). The studies are as mentioned below:
The skin sensitization potential of test chemical was evaluated by authoritative database using Guinea pig maximization test. The test material in induction treatment was subjected onto the skin of guinea pig by intra-cutaneous injections of 0.1 ml of 0.1 % aqueous solution three times per day for 5 successive days followed by one intracutaneous challenge injection of the same solution after 4 weeks of induction treatment. No skin allergic reactions were observed. Hence, the test material was considered to be not skin sensitizing.
The above result was further supported by another skin sensitization study reported by same authoritative database for another read across chemical. In this study, the skin sensitization potential of test chemical was assessed in a 16 year period study. During the entire study, the cosmetic use of test chemical did cause a single case of contact allergy in humans within the 16 year period. Hence the test chemical was considered to be not sensitizing to the human skin.
Based on the above summarized studies for target chemical Hydrogen bis[3-[[1-(3-chlorophenyl)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-4-yl]azo]-4-hydroxy-N-methylbenzenesulphonamidato(2-)] cobaltate(1-) (CAS No: 85959-75-7) and its structurally and functionally similar read across substances,it can be concluded that the testchemical is unable to cause skin sensitization and considered as non-skin sensitizer. Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the skin sensitization potential of the test chemical Hydrogen bis[3-[[1-(3-chlorophenyl)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-4-yl]azo]-4-hydroxy-N-methylbenzenesulphonamidato(2-)] cobaltate(1-) (CAS No: 85959-75-7). The studies are as mentioned below:
The skin sensitization potential of test chemical was evaluated by authoritative database using Guinea pig maximization test. The test material in induction treatment was subjected onto the skin of guinea pig by intra-cutaneous injections of 0.1 ml of 0.1 % aqueous solution three times per day for 5 successive days followed by one intracutaneous challenge injection of the same solution after 4 weeks of induction treatment. No skin allergic reactions were observed. Hence, the test material was considered to be not skin sensitizing.
The above result was further supported by another skin sensitization study reported by same authoritative database for another read across chemical. In this study, the skin sensitization potential of test chemical was assessed in a 16 year period study. During the entire study, the cosmetic use of test chemical did cause a single case of contact allergy in humans within the 16 year period. Hence the test chemical was considered to be not sensitizing to the human skin.
Based on the above summarized studies for target chemical Hydrogen bis[3-[[1-(3-chlorophenyl)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-4-yl]azo]-4-hydroxy-N-methylbenzenesulphonamidato(2-)] cobaltate(1-) (CAS No: 85959-75-7) and its structurally and functionally similar read across substances,it can be concluded that the testchemical is unable to cause skin sensitization and considered as non-skin sensitizer. Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The skin sensitization potential of test substance Hydrogen bis[3-[[1-(3-chlorophenyl)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-4-yl]azo]-4-hydroxy-N-methylbenzenesulphonamidato(2-)] cobaltate(1-) (CAS No: 85959-75-7) and its structurally and functionally similar read across substanceswere observed in various studies. From the results obtained from these studies it is concluded that the chemical Hydrogen bis[3-[[1-(3-chlorophenyl)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-4-yl]azo]-4-hydroxy-N-methylbenzenesulphonamidato(2-)] cobaltate(1-) (CAS No: 85959-75-7) is not likely to cause skin sensitization and hence can be classified as non-skin sensitizer.
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