Registration Dossier
Registration Dossier
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EC number: 269-214-1 | CAS number: 68201-37-6
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No effects are expected up to the water solubility limit of Octadecanoic acid, branched and linear (2.5 mg/L).
Key value for chemical safety assessment
Additional information
Two studies, investigating the term toxicity to microorganisms of Fatty acids, C16-18 and C18-unsaturated, branched and linear (CAS No. 68955-98-6) and Isooctadecanoic acid (CAS No. 30399-84-9) were used as readacross in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. grouping of substance and read across approach, for Octadecanoic acid, branched and linear (CAS No. 68201-37-6).
The first read across study investigated the toxicity of the Fatty acids, C16-18 and C18-unsaturated, branched and linear (CAS No. 68955-98-6) to microorganisms in a cell multiplication inhibition test with Pseudomonas putida according to ISO 10712. Due to the low water solubility of the test substance, the test solutions were prepared as Water Accommodated Fractions (WAF). Within the 16 hours test period, while being exposed to a 10000 mg/L Water Accommodated Fraction loading rate, no effects on the growth rate of Pseudomonas putida up to the limit of the water solubility of the test substance were observed (Mead, 1997).
The second read across study, is less suitable due to the lower water solubility, but nevertheless valid and is cited here to support the findings of above mentioned study. For this study cultures of the Pseudomonas putida were exposed to concentrations of Isooctadecanoic acid ranging from 0.001 to 4.8 mg/L (oversaturated concentration of test substance) for 18 hours (Coenen, 1988). After 18h no effect on the growth inhibition of Pseudomonas putida was observed. Thus, it can be concluded that no toxicological effects on microorganisms are expected up to the water solubility of the test substance, Isooctadecanoic acid.
Thus, it can be concluded that no toxicological effects on microorganisms are expected up to the limit of water solubility of Octadecanoic acid, branched and linear (CAS No. 68201-37-6).
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