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EC number: 246-307-5 | CAS number: 24544-08-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test item was tested in a skin and eye irritation study on three NZW rabbits. Both studies were conducted in accordance with GLP and following OECD-guidelines. Only slight irritating effects were observed in the two studies, therefore the test item can was considered to be non-irritant to rabbit skin.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Ltd.).
- Sex: females
- Weight at study initiation: 2.2 up to 2.9 Kg
- Fasting period before study: none
- Housing: gang housing à 5 animals per cage and sex
- Diet (e.g. ad libitum): "ssniff K 4" from SSNIFF Spezialdiäten GmbH, Soest/Westfalen, Germany
- Amount of diet: ca. 100 to 120 g per animal and day, once daily
- Water (e.g. ad libitum): tap water
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3°C
- Humidity (%): 50%
- Air changes (per hr): 10 changes per hour
- Photoperiod (hrs dark / hrs light): 12 hours (artificial light) - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 500 ul
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 1, 24, 48, 72 hours and 7 days
- Number of animals:
- 3 female rabbits
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24-72 hours
- Score:
- 0.6
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24-72 hours
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- Th test item showed slight erythema with max. score of 1 in all three animals 24 hours after treament. These effects were reversible within 48 hours in one animal and within 72 hours in the other two animals.
- Other effects:
- None
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item is not irritant to rabbit skin.
- Executive summary:
The skin irritation study was conducted as GLP-study according to OECD no. 404. The test was performed on three NZW rabbits. Slight erythema were observed in all three animals with a mean score of 0.6. These effcts were found to be reversible within 72 hours. Oedema were not seen in all three rabbits. Therefore, the substance can be considered as non-irritant to rabbit skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Ltd.).
- Sex: females
- Weight at study initiation: 2.2 up to 2.9 Kg
- Fasting period before study: none
- Housing: gang housing à 5 animals per cage and sex
- Diet (e.g. ad libitum): "ssniff K 4" from SSNIFF Spezialdiäten GmbH, Soest/Westfalen, Germany
- Amount of diet: ca. 100 to 120 g per animal and day, once daily
- Water (e.g. ad libitum): tap water
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3°C
- Humidity (%): 50%
- Air changes (per hr): 10 changes per hour
- Photoperiod (hrs dark / hrs light): 12 hours (artificial light) - Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 500 ul
- Duration of treatment / exposure:
- 4 hours
- Observation period (in vivo):
- 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- 3 female rabbits
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24-72 hours
- Score:
- 0.23
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24-72 hours
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24-72 hours
- Score:
- 0.1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24-72 hours
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- One animal showed slight corneal opacity up to 48 hours after treatment. Redness of the conjunctiva was noted in two animals, being reversible within 48 hours.
- Other effects:
- None
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item is not irritant to rabbit skin.
- Executive summary:
The eye irritation study was conducted as GLP-study according to OECD no. 405. The test was performed on three NZW rabbits. Slight corneal opacity and conjunctival redness were observed in to animals. These effcts were found to be reversible within 48 hours.
Therefore, the substance can be considered as non-irritant to the eyes.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Key study: Skin irritation – in vivo
The skin irritation study was conducted as GLP-study according to OECD no. 404. The test was performed on three NZW rabbits. Slight erythema were observed in all three animals with a mean score of 0.6. These effcts were found to be reversible within 72 hours. Oedema were not seen in all three rabbits. Therefore, the substance can be considered as non-irritant to rabbit skin.
Key study: Eye irritation – in vivo
The eye irritation study was conducted as GLP-study according to OECD no. 405. The test was performed on three NZW rabbits. Slight corneal opacity and conjunctival redness were observed in to animals. These effcts were found to be reversible within 48 hours.
Therefore, the substance can be considered as non-irritant to the eyes.
Justification for selection of skin irritation / corrosion endpoint:
GLP study following OECD-guideline; Klimisch 1
Justification for selection of eye irritation endpoint:
GLP study following OECD-guideline; Klimisch 1
Justification for classification or non-classification
Based on the data available, the substance does not have to be classified and labelled according to Directive 67/548/EEC (DSD) or Regulation 1272/2008/EC (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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