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EC number: 237-641-2 | CAS number: 13877-91-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity of Ocimene: a study similar to OECD TG 401 was performed: LD50 = ca. 5000 mg/kg
Acute dermal toxicity of Ocimene: a study similar to OECD TG 402 was performed: LD50 > 5000 mg/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 5.0 g/kg bw
- No. of animals per sex per dose:
- 10 animals (sex unspecified)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 5/10 animals died on day 1 of the observation period after exposure to 5.0 g/kg
- Clinical signs:
- None
- Interpretation of results:
- other: Not acutely harmful
- Remarks:
- in accordance with CLP (1272/2008 and its updates)
- Conclusions:
- The acute oral toxicity test showed an LD50 of ca 5000 mg/kg bw. In accordance with GHS the substance needs to be labelled with H303: May be harmful.
- Executive summary:
A pre-guideline study, equivalent to OECD guideline 401, was performed to identify the acute oral toxicity of the test substance. In this study 10 rats (sex unspecified) were administered with 5.0 g/kg bw. 5/10 animals died on day 1 of the 14 day observation period. No clinical signs were observed. Under the conditions of the test, the acute oral LD50 for the test substance in rat was determined to be ca 5000 mg/kg bw. Based on these results, the test substance is not considered to be acutely harmful.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 5.0 g/kg bw
- No. of animals per sex per dose:
- 7 animals (sex unspecified)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1/7 animal died on day 7 of the observation period
- Clinical signs:
- - Anorexia in the animal which died
- Moderate redness and moderate edema was seen in all 7 animals. - Interpretation of results:
- other: Not acutely harmful
- Remarks:
- in accordance with CLP (1272/2008 and its updates)
- Conclusions:
- The acute dermal toxicity test showed an LD50 > 5000 mg/kg bw.
- Executive summary:
A pre-guideline study, equivalent to OECD guideline 402, was performed to identify the acute dermal toxicity of the test substance.In this study 7 rabbits (sex unspecified) were administered with 5000 mg/kg test substance on the skin. 1/7 animals died on day 7 of the 14 day observation period after exposure to the test substance. Anorexia was observed in this animal and moderate redness and moderate edema was seen in all 7 animals. Under the conditions of the test, the acute dermal LD50 for the substance in rabbits was > 5000 mg/ kg bw. Based on these results, the test substance is not considered to be acutely harmful.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
The OECD TG 401 with Ocimene:
A pre-guideline study, equivalent to OECD guideline 401, was performed to identify the acute oral toxicity of the test substance. In this study 10 rats (sex unspecified) were administered with 5.0 g/kg bw. 5/10 animals died on day 1 of the 14 day observation period. No clinical signs were observed. Under the conditions of the test, the acute oral LD50 for the test substance in rat was determined to be ca 5000 mg/kg bw.
The OECD TG 402 with Ocimene:
A pre-guideline study, equivalent to OECD guideline 402, was performed to identify the acute dermal toxicity of the test substance.In this study 7 rabbits (sex unspecified) were administered with 5000 mg/kg test substance on the skin. 1/7 animals died on day 7 of the 14 day observation period after exposure to the test substance. Anorexia was observed in this animal and moderate redness and moderate edema was seen in all 7 animals. These local effects are used to support the absence of corrosion. Under the conditions of the test, the acute dermal LD50 for the substance in rabbits was > 5000 mg/ kg bw.
Justification for classification or non-classification
Based on the available information classification and labelling for acute oral and dermal toxicity is not warranted in accordance with EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008 and its amendments.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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